Ruthless drug lord Pablo Escobar floods the United States with cocaine and terrorizes the nation of Colombia.

Known as the Godfather of crystal meth, drug baron Joaquin "El Chapo" Guzman's drug empire left a trail of carnage in Mexico and turned American cities into powder kegs. With millions of dollars and plenty of places to hide, he quickly became America's public enemy number one. On the job, DEA agents Joe Bond, Michael Vigil and Gilberto Gonzalez, tell the story behind the legendary "Operation Gargoyle."

In 1980 the trickle of cocaine coming in to Florid a suddenly becomes a flood and drug wars erupt on the streets. Carlos Lehder is behind it all. The DEA must take him down before he destroys the USA with the drug he calls Latin America's ‘atomic bomb'.

A DEA agent's murder in 1985 prompts an intense search for a Mexican drug lord

A Colombian drug lord, Griselda Blanco, brings cocaine into the United States and uses violence against her competitors.

A profile of Boston crime boss James "Whitey" Bulger, who was on the run for 16 years before being arrested in 2011 after more than a decade on the FBI's most-wanted list.

Cocaine trafficking in the 1970s and 80s is aided by Honduran kingpin Juan Ramón Matta-Ballesteros, who has close ties to drug cartels in Colombia and Mexico.

A profile of Frank Lucas, a heroin kingpin in Harlem in the 1960s and 70s whose life of crime was depicted in the 2007 film "American Gangster."

An FBI sting operation at a Costa Rican hotel disrupts a 2002 deal to swap arms for cocaine involving a Colombian paramilitary group

Russian arms dealer Viktor Bout is targeted by a DEA sting operation in 2008 in Thailand on the suspicion of trying to sell weapons to Colombian terrorists.