Tu mejor amigo: Reparto
Josh Gad
Dogs: Bailey / Buddy / Tino / Ellie (voice)
K.J. Apa
Teen Ethan
Britt Robertson
Teen Hannah
Dennis Quaid
Adult Ethan
Peggy Lipton
Adult Hannah
Juliet Rylance
Elizabeth - Ethan's Mom
Luke Kirby
Jim - Ethan's Dad
John Ortiz
Carlos
Kirby Howell-Baptiste
Maya Williams
Pooch Hall
Al
Logan Miller
Todd
Gabrielle Rose
Grandma Fran
Caroline Cave
Ellen - Boss' Wife
Nicole LaPlaca
Wendi
Michael Patric
Sam
Michael Bofshever
Grandpa Bill
Primo Allon
Victor
Kalyn Bomback
Yolanda
Peter Kelamis
Dad's Boss
Jane McGregor
Rachel
Kelly-Ruth Mercier
Atlanta Vet
Kwesi Ameyaw
Cop
Paul Jarrett
Police Lieutenant
Anita Daher
Mother at Shelter
Alicia Johnston
Hysterical Mother
Naomi Frenette
Kidnapped Girl
Brooke Warrington
Bree
Bryce Gheisar
Ethan - 8 Years Old
Robert Mann
Delivery Workman
Ron Verwymeren
Delivery Workman
David J. Lyle
Country Vet
Cory Wojcik
Puppy Mill Owner
Ross Douglas Noble
Puppy Mill Customer
Andrew W. Nolan
Football Coach
Jordan Butterill
Teammate
John C. MacDonald
Teammate
Brent Holtzman
Police Captain
Christopher Pearce
Policeman
Violet Haas
Elderly Woman
Darcy Higginbotham
Farm Hand
Danesha Lee
Animal Control Officer
Dan De Jaeger
Father at Shelter
Reine Lecuyer
Daughter at Shelter
Rayna Ens-Armstrong
Daughter at Shelter
Mackenzie Thornton
Tweener Girl
Avery Thompson
Tweener Girl
Aidan Ritchie
Ambulance Attendant
Kenyan Alexander Walcot
Ty - 5 Years Old
Treyton Augustus Walcot
Richie - 4 Years Old
John Bluethner
Professor
James Janssens
Alzheimer's Patient
Paul Griggs
Hot Dog Vendor
Grant Burr
Hardware Store Clerk
Ronald Boyd Johnson
Neighbor
Chris Webb
Kidnapper
Evan Martin
Punk Boy
Tyson Wagner
Boyfriend in Park
Dean Mckenzie
Detective
Tom Young
Hardware Store Employee