The new assistant administrator Ann Anderson arrives at Kensington General Hospital and is taken aback by the eccentricities of her staff.

Charley refuses to treat his old high school teacher.

Charley finds himself entertaining two different dates in the same restaurant.

Charley and Norman both face crises of confidence.

Charley becomes jealous when Ann is attracted to a famous doctor visiting the hospital.

Charlie, Ann, Norman, Amos, and Mrs Phipps are trapped in the cafeteria when a seven-year-old accidentally exposes them to smallpox.

Charley must perform surgery on a convicted mobster.

The new hospital administrator forces Amos to retire.

The staff try to catch a thief and a mysterious unidentified doctor.

Charley causes unrest among the nurses when he is laid up with a bad back.

A con woman tries to extort money from the hospital by faking an accident.

Amos's clumsy granddaughter tries to prove herself capable of carrying on the Wetherby medical tradition.

Charley goes to jail for refusing to divulge a patient's medical history to a senator.

A new female doctor causes trouble for everyone.

A mugger is loose in the hospital.

Ann defends a nurse about to be fired for posing nude in a men's magazine.

The staff mount a Chrismas show to entertain the patients.

A madman plants a bomb in the hospital.

Charley fakes an operation to prevent Mr. Peckler from interfering with procedures.

Ann and Charley help a wanted man sneak into the hospital to visit his dying father.

A government agent sneaks into the hospital to talk to a seriously ill patient.

Petty thefts around the hospital point to a strange group of suspects: a strange outpatient who harraseses the staff, a recovered kleptomatic who's mother is a hospital benefactor, and an orderly with a history of police trouble.

Peckler tries to fire a new doctor when he learns the physician is gay.

Charley loses confidence when his patient brings in a team of specialists.

Conrad Peckler learns the head of the drug rehabilitation program is a homosexual and threatens to have him fired. Norman tries to help Mrs. Phipps after she is tricked by a con man patient.

Norman's in trouble when he puts the hospital chef on a strict diet—and the man promptly suffers a heart attack.

Charley tries to prove that a doctor is performing unnecessary operations.

Charley decides that Amos's young girlfriend is a golddigger.

Charley tries to convince a campaigning senator that he needs immediate surgery.

A patient believes he is a werewolf.

While Norman tries to prove to his mother that he is an adult, a neurotic patients adopts Charley as a substitute father.

While Charley suffers from insomina, Norman gets a bad case of overconfidence.