Several thousand years after a mysterious phenomenon turns all of humanity to stone, the extraordinarily intelligent, science-driven boy, Senku Ishigami, awakens from petrification. Facing a world of stone and the total collapse of civilization, Senku makes up his mind to use science to rebuild the world. Starting with his super strong childhood friend Taiju Oki, who awakened at the same time, they will begin to rebuild civilization from nothing. Depicting two million years of scientific history from the Stone Age to present day, the unprecedented crafting adventure story is about to begin.

Facing immediate danger from wild animals Senku and Taiju are forced to revive Tsukasa Shishio "The Strongest High School Primate". Although Tsukasa has tremendous fighting ability and provides abundant food as their hunter, their new ally harbors an opposing view on restoring humanity.

Senku does not trust the motivation of Shishio, so he will try to hide his plans from a new and unforeseen enemy for his plan to revive civilization.

Senku has the idea of ​​creating gunpowder to have a way to balance the scale and have a chance to defeat Shishio. The production of gunpowder causes a fire. Shortly thereafter, Senku and the others discover smoke signals on the horizon. An accident? Hardly likely. Apparently there are other people in the stone world ...

Shishio is determined to end Senku's life if he does not promise at that moment that he will abandon his idea of ​​recovering civilization as it was before the incident.

Taiju and Yuzuriha figure out Senku's secret to reviving him. But now that he's back, they need to deal with Tsukasa.

Kohaku shows Senku to her village, but it's going to take some convincing before they let him in. In the meantime, he makes friends with a like-minded, promising "sorcerer."

Kohaku's sister, village priestess Ruri, is gravely ill. Senku, Chrome and Kohaku begin their quest to make antibiotics to save her life.

Senku starts a ramen stand in hopes of winning over support for his kingdom of science, but some people are too principled to take such a bribe. Mentalist Asagiri Gen is not one of them.

Senku and his kingdom of science successfully test the first lightbulb since the collapse. Meanwhile, Asagiri Gen, a spy from Tsukasa's empire, is killed by an unknown attacker.

The development of glassworks, an important step for making sulfa drugs and for chemistry as a whole, turns out to have a surprising benefit for Suika.

To make antibiotics, Senku and his kingdom need to obtain sulfuric acid from a fountain of the stuff. The team goes prepared, but there's no guarantee that they'll make it back alive.

All that's needed to make antibiotics is alcohol. The best way to get some is to win the Grand Bout, which the Senku and his kingdom will also need to do in order to keep Magma away from Ruri and give her the drug.

After Magma's series of tricks to reach the final match, Chrome reveals a trick of his own! With a little extra help from Gen, Chrome just may be able to pull this one off!

After Senku's unlikely victory, quick marriage, and even hastier divorce, the kingdom of science is back to work to finally finish Ruri's medicine!

Ruri reveals the origin of the village's name and Senku learns of his father's fate!

Byakuya and the astronauts' story continues, and Senku's connection to Ishigami Village and the Hundred Tales is finally revealed.

Tsukasa's army is coming! Kinro struggles to hold the bridge against the deadly spearman Hyoga and his shock troops, but Senku and the villagers are ready with deadly new weapons of science!

Hyoga is disarmed, but the kingdom of science is still in danger - Ishigami village is in flames! And Tsukasa will soon know that Senku is still alive... How will the villagers fight off the coming invasion?

Work begins on creating the components for Senku's cell phone, but spinning gold wire is proving to be quite the task! Luckily, Chrome and Kaseki "invent" the water wheel and drastically improve the process!

With Chrome and Kaseki’s water wheel finished, Ishigami Village moves into the age of electricity! But with the primitive materials available to him, will Senku be able to create a filament that can withstand the intense heat of operating a vacuum tube?

Senku, Chrome, and Magma venture into a cave in search of Tungsten, but there's a suspicious accident that leaves Senku and Chrome trapped at the bottom of a pit! What is Magma up to?!

Senku and the rest of the village get to work on making the components for the cell phone. It's hard work but everyone is pumped!

After a successful test of their new cell phone, Senku learns of a mysterious tale about a bee named Speaker who can play the voices of the dead.

Senku continues in trying to advance the Stone World, this time he makes "space food", it is in actuality cup noodles. After Senku finishes his project, Gen has an epiphany and devises a plan to take down Tsukasa's army without violence.

While Senku's diversion buys Gen and others some time, soon Homura realizes something is not right.

Taiju and Yuzuriha are on the verge of tears after they hear Senku's voice, and Senku informs them of his plan to win the war without any bloodshed.

Chrome and Magma struggle with Ukyo, while Senku, gets his hands busy with building up an invention; a new hope.

The final touches to the automobile are made and it is used to transport the science supplies to a fortified cliffside that's close to the Tsukasa empire. From there the automobile is upgraded into a tank, but unbeknownst to the rescue group preparations by the empire have been made to counter any vehicular attack.

Chrome must use all of his scientific knowledge to escape from his prison and save Senku and others.

Senku decides to use the Steam-Gorilla to capture The Miracle Cave. Using Lillian's recording, Senku gains the trust of more of Tsukasa's men. Ukyo reveals he saw Yuzuriha's secret mission to reassemble the fragments of statues Tsukasa destroyed.

The Final Battle for the miracle cave starts as Senku and the Kingdom of Science conduct a frontal assault on the cave.

Tsukasa and Hyoga are coming to capture the miracle cave. The Kingdom of Science must buy Senku and Chrome some time to turn the tide, or it is all over.

Senku demands a truce from Tsukasa in return for reviving his sister, Mirai, who Tsukasa comes to know is alive, but a new problem shows up when Hyoga shows his true self.

The Kingdom of Science is victorious, however it is not over for Senku. Senku must use all of his knowledge to cure Tsukasa who is severly injured.

While continuing to use the hot air balloon to search for the oil, it's decided that Ishigami Village needs to take up agriculture to prevent future food shortages, as well as to produce preserved food for their upcoming sea voyage.

The Kingdom of Science will need rations to last them through their voyage to the other side of the world. But Senku, being no professional, burns all the bread he attempts to bake.

Senku, brings along a team to look for the Sagara Oil Fields. Meanwhile, Suika and Francois go truffle hunting.

The morse code signal reading "WHY" saturates the airwaves too much for Ukyo to pinpoint a direction, so the Kingdom of Science works on a way to visualize the signal.

Kaseki's efforts to build the science vessel Perseus hit a roadblock when he realizes that it's impossible to get all the parts to fit in practice.

The Perseus crew are on their way to the treasure island, the birthplace of the Hundred Tales, where they hope to locate the treasure box left behind by the Soyuz crew.

The Perseus arrives at the treasure island. A recon squad consisting of Senku, Soyuz, Kohaku, and Gen set off to locate the platinum and make contact with the islanders. Ukyo later discovers something on the seafloor and send Ginro to investigate.

Amaryllis explains how she evaded petrification and how she came to her decision to sneak into the inner palace.

Suika and Ginro work together to rescue the mobile lab from the Perseus. Reunited with Senku and the others, the group works on items to help Kohaku with the selection process.

Amaryllis, Ginro and Kohaku are chosen to join the inner palace. The science team will need a way to communicate with them in secret, and, eventually, a way for them with the science team.

Kohaku has located the treasure left behind by Byakuya and the others, but it's encased in concrete. Senku has to devise a plan to quietly get at the contents inside, so as to not alert the guards.

Kohaku is forced to destroy Ryusui's statue to prove that she isn't a spy.

The team revives Kaseki to work on the drone. Meanwhile, Ginro is called to see the Master.

More of the Kingdom of Science is brought back from petrification, but they are discovered in the cave by Moz.

Moz and the Kingdom of Science form a tenuous, temporary alliance against Ibara. How long it will last is a question they can't afford to concern themselves with just yet.

The Kingdom of Science attacks and tries to execute their plan to steal the petrification device. Moz convinces Kirisame to use the device, but Ryusui's instincts tell him something is off about the situation.

The Kingdom of Science members launch an attack on the islanders aboard the Perseus, but Moz isn't far behind and Senku and the others are forced to retreat inside the vessel. Ibara has them cornered, but Senku unleashes his Joker card.

Yo and the Kingdom of Science capture the petrification device, but Ibara isn't going down without a fight.

Much to Ibara's shock and dismay, Senku devised a plan and managed to escape petrification. Now the two enter into a head-to-head battle for control of the Medusa device.

Senku stands victorious. He then works on reviving the others and fixing their communications device, but while they are talking with Ruri they encounter a strong interference with the signal.

To the moon! That's the plan, at least. Senku and the Kingdom of Science need to devise a means with which to go to the moon and deal with Why-Man. The first step is allying with the people of Treasure Island and enlisting their help with some new crafts.

With the petrification device in the Kingdom's hands, it's time to revive Tsukasa. But there's just one problem: the device is out of batteries.

Senku and his companions finally set off for America in search of corn. However, a dispute arises between Ryusui and Senku shortly after they depart.

Maintaining morale will be critical on the long journey to the Americas. Knowing where on the ocean you are is pretty important, too. The crew of the Perseus discuss.

The Perseus lands in the Americas. They first head to Northern California in search of yellow dent corn, but discover a lot more than that.

The search party narrowly escaped enemy machine gun fire. Unfortunately, the respite was short-lived.

Tensions rise as Dr. Xeno makes his introductions to the Perseus.

Stanley orders Luna to infiltrate the Perseus and identify Doctor Taiju. Things go sideways when it turns out to be a little too easy.

Senku had gotten his start in rocket building through an email exchange with Doctor Xeno. Their approaches to science soon diverged.

NASA scientist Dr. Xeno attempts to pick off the leader of the Kingdom of Science.

With Senku having been shot, the Kingdom of Science plots its retaliation against Dr. Xeno.

With Senku still confined to the bed, Chrome's team begins work on the tunnel to Xeno's base.

Ryusui and Senku take to the skies in a science versus science dogfight while Xeno's forces mount a ground counterattack.

Xeno's army attacks and when all seems lost, Chrome and his friends finish the tunnel and capture Xeno.