Hotshot FBI agent Brooke Haslett's search for a missing woman brings her to Indianapolis, where she follows a hunch about a U.S. senator's involvement in the disappearance of a young woman. The investigation takes an unexpected turn when Jess Mastriani, a young local woman, begins having dreams about a missing girl after getting struck by lightning. She is shocked to learn that the dreams are giving her metaphorical clues to the girl's location but an impulsive decision ruins the situation for all involved. When the FBI finds out about her dreams they ask her to work for them as a special consultant & Brooke is made her partner. She also dreams about the missing woman Brooke is searching for. But Brooke finds it difficult to take these clairvoyant dreams seriously as each one points toward events in the past.

The new team's first official case is a missing FBI cadet whose disappearance puts them on the trail of a serial killer.

A nightmare has so rattled Jess that she is unable to fall asleep, increasing the pressure on her to locate a missing woman threatened by a killer as having only a few hours left to live.

In the team's most perplexing case so far, a teenage girl's parents suddenly vanish from their car while the vacationing family is stopped at a gas station on the highway.

Brooke and Jess must discover how a woman disappeared from an airplane in mid-flight. Meanwhile, Brooke finally learns the identity of the secret admirer who has been sending her gifts.

Brooke and Jess are ordred to help another FBI agent locate a dead mobster's wife, although they're not sure whether she was abducted or simply decided to run off with a bunch of her husband's money.

The team is called upon to locate the missing husband of a woman in the Witness Protection Program, without leading the bad guys to her location.

Brooke is attending a wedding with Eric Reynard and the bride doesn't show up for the vows. When the groom goes to talk to her there is a crash and Brooke finds him unconscious. The team starts searching. Later a ransom note (or e-mail) arrives.

When Rebecca Crowley insists that she spotted her brother Richard, who has been MIA for years, Brooke and Jess are called in to investigate the claim. Despite the Army's official story that Richard died during a special ops mission in Bolivia, Brooke and Jess learn that he became involved in the drug trade, causing them to wonder whether Richard's disappearance was intentional. The more they discover, the more Brooke and Jess realize that he may not be the person they should be looking for.

Brooke takes on the authorities after a death-row inmate makes a final plea. As time runs out, Brooke and Jess risk it all to try to save the innocent man.

Brooke and Jess investigate the disappearance of a wealthy couple who were on a nature trip. Things get complicated when Jess and Brooke find themselves on their own in the woods with a killer on the loose.

Jess' dreams lead to the disappearance of a psychotic and potentially dangerous patient from an asylum

Brooke's past rears its ugly head when a brilliant serial killer whom she was never able to prove guilty is on the loose again. The cat-and-mouse game becomes especially dangerous when someone close to Brooke goes missing.

When a young cadet goes missing from a military academy, Jess goes undercover to find out whether she went AWOL or if there was another reason for her disappearance.

When a research scientist who holds the key to a potentially highly profitable drug is kidnapped, Brooke and Jess must contend with several suspects: drug smugglers, the scientist's wife, Brooke's father and his co-workers.

Brooke searches for a missing journalist who was about to publish a book containing proof of FBI corruption. Although Jess' dreams indicate that someone within the bureau may be responsible for the disappearance, Brooke can't believe it. Also, Jess goes undercover with obnoxious agent Jack Burgess to bust a drug ring.

Under heightened stress as the frequency of her waking visions increases, Jess meets an FBI inspector who tells her about a secret investigation of Brooke. Jess can't discern whether this is a dream or reality and begins to believe she is going crazy. What's really happening: Jess' visions are helping the bureau track down a female serial killer, and the killer's dark paranoia is entering Jess' mind.

After a mother and son of an attorney go missing, Brooke and Jess must work with a legendary FBI agent to solve the case. Jess believes she is being stalked by a homeless person but it turns out she is a former psychic for the FBI, a living warning of the cost of working for the FBI. Brooke is offered a promotion that would move her to San Francisco and end the her and Jess' partnership.

Jess goes to Quantico to train to be an FBI agent after Brooke transfers to San Francisco. Jess is passed from the training school by powerful John Pollock to work with her new partner, rule-breaking hip Nicole Scott as well as evidence expert Antonio Cortez. In the team's first case, a teenaged girl is caught on a survelliance camera stepping on an elevator with a stranger at a shopping mall. The elevator goes down a floor and opens to reveal an empty car. The girl is not seen for days after this incident. Nicole and Jess must work together to use Jess' visions and Nicole's experience and street smarts to solve this case.

A woman fearing for her life makes a panicked 911 call. The next day blood is found in the hotel room she shared with a fraternity boy on a one night stand. Nicole and Jess expect that they are searching for a body but find out that they have been misled. Nicole and Jess could be in danger from a serial killer on the loose.

A judge who must decide whether or not an elusive criminal should face a trial has her daughter kidnapped. Nicole & Jess later find out that the kidnappers got the daughter's best friend instead of her. The judge must face the terrible decision of letting an evil criminal go free or letting a teenaged girl die unless Nicole & Jess find her in time.

A woman sees her son, whom she believed died ten years earlier in a car accident along with his father, on television at a football game. The boy's father's body was found and the boy was assumed to be dead in the horrific car accident. Nicole and Jess must find both the boy and his father's murderer. Also, Nicole believes Jess' dreams are about her and doesn't feel flattered.

A public bus that was traveling from Boston to Atlantic City, New Jersey is found in rural New Jersey with the twenty passengers (including an 8-month pregnant woman) and the driver mysteriously absent. Nicole and Jess find out that a man traveling from Boston to Miami on a bus from the same company that left at the same time was beat up and had his luggage stolen. Jess has no idea what her dreams involving a man eating garbage and screaming coming from behind a red door mean. Jess and Antonio discourage Nicole from re-starting her smoking habit which she gave up five years earlier.

A woman is found murdered in New York City's Central Park but before police arrive at the scene the medical examiner, the hearse, and the driver disappear along with the body. Eventually the body along with the boides of the medical examiner and the driver are found cut open. Assistant Director Pollock identifies the body as that of an unprofessional undercover woman he had been using to get information about a gang of bank robbers. Jess has dreams about the snitch getting the electric chair and of Pollock kissing the woman.

A rebellious teenager has an argument with her parents, storms out of their suburban home and drives away. When she returns hours later her parents and younger brother have disappeared. The teenager and her boyfriend are the top suspects until a body is found that breaks the case wide open. Also, an infamous red light camera sheds some new light on the case (and on their feasibility). Nicole and Jess have to deal with a rude Drug Agency officer who won't let them investigate a murder Jess dreams about because of its drug relations.

An empty police car is found with blood on the dashboard and two police officers have gone missing. Jess and Nicole quickly discover a police department full of corruption. After Jess witnesses a shocking murder, she must find out which of the many suspect or suspects is a cop killer. The police chief suspects an old enemy of his who shows up in Jess' dream about the police officers having a party. Also, Nicole must negotiate with a crazed man holding three people hostage.

A senator's senior aide's five year old daughter is kidnapped. The unlikely kidnapper leads Jess & Nicole to a missing reporter who was working on an article about Chinese people being smuggled into the United States. The team discovers that the reporter may have gone a bit too far undercover. Jess dreams about a dead man pointing at something. Nicole & Antonio put their jobs on the line to solve this case when John forbids them to work on the case any longer.

After a horrific car accident, a famous pop star's bodyguard is seriously injured. Meanwhile, the singer, who was in the car, has vanished. The investigation leads them to an obsessed fan who has been sending the singer letters that could be perceived as threats. Nicole & Jess also stumble onto a sad story of a reluctant adoption during the search and another person goes missing. Jess dreams about a psychic with tarot cards.

Jess, Nicole, and Antonio search for a missing woman who was delivering subpoenas. They soon discover that one of her deliverees has also disappeared. The case exposes a world of loneliness, corruption, and identity theft. Also, Jess worries that her job is dwindling her social life.

The team searches for a missing veterinarian and a missing working woman from the same Maine town. The veterinarian disappeared from a dock behind his house when his wife stepped away for a few minutes and the woman was reported missing from work. Meanwhile, Nicole is amazed when she learns than Antonio was married and divorced. Also, Jess dreams about blood. Later, the shocking discovery of a body turns the case upside down and a former F.B.I. agent joins the team in the thrilling first part of "Truth or Dare".

Jared Hart and some assassins attempt to eliminate another member of the witness protection system. Nicole and Jess follow in their footsteps while Antonio and John try to figure out how Hart is locating the innocent victims. Meanwhile, the search continues for Jared's wife and one or more members of the team may not survive the shocking case in the breathtaking conclusion of "Truth or Dare".

Nicole goes undercover when a criminal she formerly went undercover with kidnaps an innocent woman because she is related to one of the agents who put him in jail. She learns of a deadly plan of revenge for his years in jail. Also, she must somehow avoid his sexual advances without blowing her cover. Meanwhile, Jess deals with the stress of being Nicole's outside contact and has a vision in which the kidnapped woman shoots and kills random people.

After arresting a dangerous man on the run, Jess and Nicole find a man shot in the head hanging on to life in the trunk of the car he was trying to steal. The man has amnesia and doesn't remember anything. The bullet leads the team to believe that he's connected in some way to the disappearance of a young heiress and they must decide if "John Doe" is innocent or guilty while trying to figure out his identity and the circumstances of his near-death.

Antonio's ex-wife's sister is kidnapped. The team wonders if she was taken by a bitter victim of his ex-wife, who is a successful District Attorney or if it was done randomnly. A later attack blows the case wide open. Jess dreams about a little girl and toys. Meanwhile, Antonio and his ex-wife must deal with the emotions that are opened up between them.

A married woman goes missing. Her suspicious husband becomes a quick suspect in the kidnapping but as Jess and Nicole probe into her past, they discover a shocking secret and are amazed to learn that the woman had created a new life for herself. A breathtaking climax in a strange house with a very disturbed man and his "family" reveals an unbelievable secret. Meanwhile, Jess dreams about a coffin and a wedding/funeral and has troubles with a boyfriend who has a very strange name.

A biophysicist disappears along with the only sample of a deadly virus she created. To complicate things, she claimed to have been followed by men in black suits; leading the team to wonder if the government was really survelling her or if she was going crazy. Meanwhile, Toni and Doug Mastriani come to town and when Douglas goes missing and Nicole is put on probation for a misunderstanding with Army Intelligence, Jess must balance work and family and find both missing people while she dreams about her brother in a hearst drinking beer.

A pregnant woman is snatched off the street. Jess' visions regarding the case are more intense than ever. As the woman is just days from delivery, the team enlists the help of the woman's fertility doctor. They begin to close in on one of her other patients, with all signs pointing to a kidnapping for ransom. Just before the ransom drop, the woman is found but her baby has been surgically removed.

The team shifts into high gear to find an abducted newborn while dealing with a traumatized mother. Jess' visions are challenged due to the infant's lack of life experiences. Nicole and Antonio continue to try and hide their relationship from Jess, who is starting to suspect something.

Jess and Nicole are called in to help when a hurricane breaches destruction on a small North Carolinian town and dozens of people go missing. Jess' visions lead them to a young boy but shockingly, he's kidnapped from the hospital. The team works hard to find him, concentrating especially on his single father, whose wife (the mother of the missing boy) left him and their son two years earlier. Jess is attracted to a man who she caught attempting to break into the father's car. Pollack scolds Janey for a judgement call she was forced to make.

A mother and her young children witness a middle-aged woman being kidnapped in a parking lot. Jess has a vision while trying to corner a suspect that nearly lets him get away. The agents discover that the woman was trying to be as anonymous and invisible as possible and they learn a horrifying secret that hits too close to home for Nicole, who reveals a deadly secret about her childhood. Meanwhile, Antonio encourages Nicole to share what's bothering her and Jess is asked out by Colin, the undercover agent she worked with in "Unnatural Disaster".

Jess has a vision that leads her and Nicole to discover a 10-year-old skeleton. When the body is identified, Pollack orders them off the case. Jess and Nicole continue to work on the case while trying to keep their work away from Pollack and trying to figure out why he's so insistent that they can't work on it. Meanwhile, Pollack's wife kicks him out.

The agents search for a wealthy businessman who disappeared from his hotel. They try to get the truth out of his girlfriend, who discovered him missing in the middle of the night. When Pollack's team is ordered off the case by his boss, he risks his job to continue working on it. Meanwhile, Pollack tries to reconcile with his wife.

The agents search for a young boy who goes missing while his grandmother babysits him. Their investigation leads them to his family, who have hired an aggressive lawyer. The shocking results of the grandmother's polygraph test leads to an even more surprising conclusion. In the end, the agents face off with a psycho and must outwit him to find the boy alive. Meanwhile, Jess tells Colin that she's psychic and is disappointed by his reaction while Nicole and Antonio worry that Pollack will transfer one of them now that they suspect he knows that they're in a relationship.

A convict about to go to trial for murder kills two police officers and escapes. He then steals a woman's car and kidnaps her. Jess, Nicole, Antonio, and Janey are assigned to the case and Jess and Nicole barely make it out alive of a burning building they enter to rescue the kidnapping victim. However, once the woman is found, the mystery has just begun. Nicole urges Jess to get to know Janey better and the three women urge Antonio to keep his job. In a jaw-dropping ending, somebody doesn't make it out alive of a drugstore shootout.

The case - finding a criminal attorney's kidnapped secretary - is complicated by Jess's visions of a recently-deceased agent with similar characteristics. Meanwhile, the entire squad must undergo a psychiatric evaluation, Nicole and Antonio's romance hits a stumbling block, and Pollock's career is in jeopardy.

A federal prosecutor is kidnapped. The team is given a new temporary boss who isn't as nice as he originally seems. Nicole and Antonio clash again over whether Antonio will leave the FBI to save their relationship. A decision is finally reached, but it does not bode well for their future.

When the teenage perpetrator of a high school hostage crisis disappears, the agents solicit some unusual help from their suspended boss, Pollock, to investigate the school psychiatrist's records. Then, when another student goes missing, suspicion falls on the mysterious Patient X.

Antonio, Jess and Colin give up their vacation time to help Nicole investigate the disappearance of her nephew.

In what may be the most bizarre case yet for the FBI squad, the team must find missing twin girls in order to figure out who killed their parents and why! Jess' visions suggest that the girls are separated but both lost in the wilderness.

Nichole Scott may not survive her latest case because of a severe concussion. Now Jess takes the lead on the case. The case concerns a man named Tom that has gone missing. As the team begins to investigate They soon learn that the dad isn't surprised when Nicole and Jess arrive at Dan's house to inform him that his son is missing. The team also finds out that the father has hired someone who turns out to be a terrorist. The agents learn that Tom has been missing in South America but their investigation takes quite a surprise when they go back to interview his father again only to find Tom has returned home. Nicole tries to hide her concussion from her boss John Pollack. When they are trying to arrest Tom for shooting his father.

Nicole and Jess are on the search for a woman named Caroline Dunn who went missing during spring break. The team believes she went missing with her boyfriend Luke. meanwhile Nicole is still ready to go back into the field while dealing with a concussion. As the search for Carolyn continues the team discovers a surprising result that they didn't expect.

Nicole and Jess travel to Budapest Hungry to track down a missing bridegroom.

This case may be the toughest one the team has had yet. When the inventor of Easy Abs is nowhere to be found the team finds a ransom note and then another ransom note. What has the team confused is the two different amounts on both ran some notes.

Nicole gets to know her mom and tries to get to know her better. They also try to find a missing Department of Justice agent and try to find out why and who blew the cover of the DOJ agent.

The team searches for his serial killer named Carol Eisenberg who along with her husband killed five girls. Now she has escaped from prison. Also Jess warns Antonio that someone may harm him. Her vision turns out to be correct when Antonio realizes he's being stalked by a dead man.