The Martini family moves to Poggio Fiorito, a residential area on the outskirts of Rome. Lele faces all the problems that the move entails. Luckily, his sister-in-law, Alice, is there to help him. The family's new housekeeper, Cetinka, causes chaos: as soon as she's hired, some money goes missing, and suspicion falls on her. But could this really be true? And are we sure she's from Poland?

Alberto, Lele's only grandchild, runs away from home and takes refuge at the Martini house because his parents are divorcing. Meanwhile, Grandpa Libero, to save money, starts selling musical pillows. Maria's birthday is coming up and she asks her father if she can celebrate alone with her friends. Lele agrees but is reluctant. Around the same time, Maria gets her period, and Rebby is the first to know.

Alice and Giulio, Lele's best friend, are worried because the doctor hasn't dated women in years, so they decide to set him up with a 35-year-old doctor named Irene. Lele's salary isn't enough to cover his family expenses. So his ex-father-in-law finds him a job at a private clinic that performs plastic surgery. Will this be the right fit for him?

Barbara, a young intern who courts Lele, arrives at the local health authority. Meanwhile, Giulio is admitted to the hospital after suffering a heart attack; will Lele's timely intervention save his life? Ciccio is struggling with his first love and would like to ask his father for advice, but Lele has other things on his mind at the moment. The trial regarding the accident that killed his wife Elena has begun.

Due to a sudden flood in his home, Giulio finds temporary shelter at the Martini house. Lele is obviously happy to lend a hand to his best friend... but only up to a point. Alice convinces Lele to sign up for a tango class with her. Sparks fly between them and they realize they're attracted to each other. But just then, Sergio, Alice's ex, arrives.

Grandpa Libero, attracted to piano teacher Maritè, takes some piano lessons from her, and Alberto and his friends start smoking against Lele's wishes. Laura, a colleague at the local health authority, is having problems with her ex-husband, and so Lele decides to help her, pretending to be her boyfriend. But it seems only Lele is pretending: Laura seems to have genuine feelings for the doctor.

Alice has an unusual mole appearing on her skin. She'll have to undergo surgery, and she wants only Lele by her side. This will trigger intense jealousy in her current boyfriend, Sergio. Sergio and Alice's relationship is becoming serious. Lele decides to openly confess his feelings to his sister-in-law, but the results aren't what he hoped for.

Sergio and Alice set a wedding date. At the Martini household, no one is happy about Alice getting married, and they're right: one evening, in fact, after returning home drunk, Sergio savagely beats Alice. Alice's wedding is annulled: fortunately, she has truly seen who she's dealing with. So, distraught, she moves into the Martini household. Meanwhile, an old flame of Lele's arrives at the clinic.

Grandpa Libero argues with his in-laws who want Maria to enroll in a very exclusive private school. Although things aren't going well, she's rather focused on her crush on a boy from her school. Irene's reappearance creates a lot of confusion in Lele's mind, so much so that he doesn't realize how unhappy Alice is. Meanwhile, Grandpa Libero's romantic relationship seems to be progressing.

Lele organizes a weekend reunion at the Martini house with all his childhood friends, offering them room and board, but over the years his friends seem to have changed significantly. Ciccio is sad because he didn't bring a good report card to his father, who scolded him. He meets Gus, a boy who lives and works at the circus, and decides to go with him and run away from home.

Great jealousy swirls in the air: Irene is angry with Lele because no doctor at the local health authority can resist his advances, while Maria is dealing with her first heartbreak. Not all the flirtations are welcome. Grandpa Libero tries to contain Marite's advances, while Alice must curb the editor-in-chief's "attentions." A surprise ending to Irene's birthday party.

Lele finally manages to spend a passionate night with Irene, but things get complicated when he decides to introduce her to his family. Meanwhile, Giulio is grappling with a serious problem. Lele's relationship with Irene has begun, but not everyone is happy about it. Especially Maria. Uncle Spartaco's arrival from America is welcomed as something to celebrate, but the visit hides a bitter surprise.

Maria continues to hate Irene, hoping that Aunt Alice will fall in love with her father, because to her they seem like a perfect match. Meanwhile, Cettina rejects her boyfriend's offer to live together. Lele discovers that Irene has hidden the news of her scholarship to Boston from him. She also doesn't intend to follow him to a friend's wedding in Milan. It's there that Alice and Lele meet again in Lele's room, alone.

Ciccio wears a hat lent to him by his girlfriend Susy, but it's full of lice, and the whole family becomes infected. Meanwhile, Alice and Giulio plan a night out, but it turns out to be a disaster. Lele and Irene argue after Irene discovers that Lele spent the night with Alice during the wedding in Milan; Irene is involved in a car accident, while Grandpa Libero's motorcycle is stolen.

A new doctor arrives at the local health authority: Dr. Oscar Nobili. One day, a gunshot is heard from the new arrival's room; it's a man attempting to commit suicide in front of Oscar. Lele will discover a secret. The Martinis go to Venice to visit Grandpa Libero's brother. After visiting the city, the Martinis separate. From this moment on, the trip turns out to be full of unexpected events, hidden just around the corner.

While Lele and Irene browse the stalls at the neighborhood festival, where Libero, Giulio, and Giacinto are also selling modern antiques, the Martinis' house catches fire. Lele is very worried: the insurance, having expired, doesn't cover the renovation costs of the burned house, and Ciccio confesses to having started the fire by playing with firecrackers.

Alberto hopes his mother has finally found the man of her life. Unfortunately, she has decided to resume her relationship with her ex-husband, which leads to a heated argument with her son. Alberto will remain at the Martini home. Irene, due to the expiration of her contract with the Rome Local Health Authority, must request a transfer. Lele tries to save their relationship and asks her if she wants to marry him.

Grandpa Nicola finally returns from Brazil, and Grandma Enrica decides to look in his suitcase and discovers a beautiful necklace. The unpleasant surprise, however, is that her husband returned three days early: he lied to her! Ciccio suspects an affair between his father Lele and his friend Susi's mother. Meanwhile, Alice is becoming famous, but her career seems to be jeopardizing her family's affections.

While Lele and Irene spend the weekend in Bologna, their new neighbors arrive, with whom Ciccio is having some problems. Meanwhile, Cettina argues with Alberto over his snobbish friends. At the Martini house, it seems like a maniac is stalking Cettina, but in reality it's just a misunderstanding. Meanwhile, Alessia Merz shows up at the local health authority, apparently interested in Lele.

A group of children from an orphanage arrive at the clinic for vaccinations. Among them is Robertino, a boy with Down's syndrome who mistakes Lele for Santa Claus and asks him for a new bus for the orphanage as a Christmas gift. Grandpa Libero has organized a show with Orietta Berti, but it looks like a scam. Alice and Irene will also have to work on Christmas Eve, and the magic of Christmas is struggling to arrive at the Martini house.

Ciccio searches for a girlfriend for Grandpa Libero in a lonely hearts magazine. Ricky, Jessica's boyfriend, ends up in a coma after a car accident. Maria, on the other hand, is invited by a boy she likes. At the radio station where Alice works, there's a health program. Lele and Alice are convinced the host is a charlatan, and even the local health authority is starting to worry about the show's success.

Alice gives Maria tickets to the Backstreet Boys concert, but Lele, worried, refuses to let her. Luckily, Grandpa Libero intervenes! Giacinto is fired, and it's up to Cettina to resolve the situation. Meanwhile, Jessica and Lele go to Ricky, who has woken up, but there's a nasty surprise lurking.

Ciccio steals from Grandpa Libero's wallet and, along with his friend Filiberto, skips school to go to the mall. But there, the two are threatened by other kids, who force them to give up the money. Lele finds a pregnancy test in Irene's locker and hopes for a child. But things aren't going to be like that, and in fact, Irene has been arrested at a doctor's office in Milan. This changes everything.

Maria hears the news of Leonardo DiCaprio's arrival in Rome to shoot a movie and goes to Cinecittà, where she meets Johnny, his bodyguard, and develops a crush on him. Meanwhile, Giulio decides to leave for Africa. Alice has been spotted with Tiberio Timperi, and Lele becomes jealous. Meanwhile, Giorgi discovers he's suffering from kidney failure, and everyone at the local health authority is worried, while Lele and Irene continue to argue.

The Martini family relaxes in the countryside, where Maria meets a boy who invites her to a party. But things go haywire: the boy becomes too insistent, to the point of becoming violent. But someone is ready to intervene. Grandma Enrica returns from Ponza with news: she's fallen in love with the owner of a fruit and vegetable supermarket, whom Alice doesn't like. Meanwhile, Lele decides to buy a ring.

Alice meets François, a doctor and friend of Giulio's who helps find families to take in African children for a while, and she decides to go with him to make a reportage. And Lele?

Lele and Alice spend the evening together celebrating their departure, but he can't bring himself to confess his feelings. But when he learns from François that Alice is in love with him, he decides it's time to confess.

Lele and Irene argue after the latter discovers that Lele spent the night with Alice during their wedding in Milan; Irene is involved in a road accident, while Nonno Libero's motorbike is stolen.

A new doctor arrives at the ASL: Doctor Oscar Nobili. One day a shot is heard from the newcomer's room, it is a man who is trying to commit suicide in front of Oscar. Lele will discover a secret.

The Martini family goes to Venice to visit Nonno Libero's brother. After visiting the city, the Martinis go their separate ways. From this moment on the trip turns out to be full of unexpected events hidden just around the corner.

While Lele and Irene visit the stalls of the neighborhood party where even Libero, Giulio and Giacinto sell modern objects, the Martini house catches fire.

Lele is very worried: the insurance, which has expired, does not cover the costs for the renovation of the burnt house and Ciccio confesses that he caused the fire by playing with firecrackers.

Alberto hopes that his mother has finally found the man of her life. Unfortunately the woman has decided to resume the affair with her ex-husband, who comes to a strong clash with her son. Alberto will still remain at the Martini house.

Irene, due to the expiry of her contract with the Asl of Rome, has to ask for a transfer. Lele tries to save their relationship and asks her if she wants to marry him.

Grandpa Nicola finally returns from Brazil, and Nonna Enrica decides to peek into his suitcase, discovering a beautiful necklace. The bad surprise, however, is that her husband returned three days before her: he lied to her!

Ciccio suspects a relationship between his father Lele and his friend Susi's mother. Meanwhile Alice is becoming famous, but her career seems to compromise her family affections.

While Lele and Irene spend the weekend in Bologna, the new neighbors arrive, with whom Ciccio has some problems. Meanwhile Cettina argues with Alberto because of his snobbish friends.

At the Martini house, it seems that a maniac is pursuing Cettina, in reality it is just a misunderstanding. Meanwhile, Alessia Merz shows up at the local health authority and seems interested in Lele.

A group of children from an institution for orphans arrive at the polyclinic for vaccinations. Among them is Robertino, a kid with Down syndrome who mistakes Lele for Santa Claus and asks him for a new bus for the Institute as a Christmas gift.

Nonno Libero has organized a show with Orietta Berti, but it would appear to be a scam. Alice and Irene will also have to work on Christmas Eve, and the magic of Christmas is struggling to reach the Martini house.

Ciccio is looking for a girlfriend for Nonno Libero in a magazine for lonely hearts. Ricky, Jessica's boyfriend, ends up in a coma after a car accident. Maria, on the other hand, is invited by a boy she likes.

On the radio where Alice works there is a column dedicated to health. Lele and Alice are convinced that the presenter is a charlatan, and even the ASL are starting to worry about the success of the show.

Alice gives Maria tickets for the Backstreet Boys concert, but a worried Lele doesn't want to give her permission. Luckily grandfather Libero intervenes!

Giacinto is fired, and it's up to Cettina to resolve the situation. Meanwhile Jessica and Lele go to Ricky who has awakened, but there is a nasty surprise lurking.

Ciccio steals from grandfather Libero's wallet and together with his friend Filiberto skips school and goes to the mall. But there the two are threatened by other kids, who force them to give them the money.

Lele finds a pregnancy test in Irene's locker, and hopes for the arrival of a child. But things are not like that, and indeed Irene was taken to a clinic in Milan. This changes everything on the table.

Maria heard the news of Leonardo Di Caprio's arrival in Rome to shoot a film and goes to Cinecittà, where she meets Johnny, the bodyguard, and develops a crush on him. Meanwhile Giulio decides to leave for Africa.

Alice was seen in the company of Tiberio Timperi and Lele gets jealous. Meanwhile, Giorgi discovers that he has kidney failure and everyone at the ASL is worried, while Lele and Irene continue to argue.

The Martini family relaxes in the countryside, where Maria meets a boy who invites her to a party. But the situation takes a turn for the worse: the boy shows too much insistence, until he becomes violent. But someone is ready to intervene.

Grandma Enrica returns from Ponza with some news, she has fallen in love with the owner of a fruit and vegetable supermarket that Alice doesn't see kindly. Meanwhile Lele decides to buy a ring.

Alice meets François, a doctor friend of Giulio's who is in charge of finding families who can take in African children for some time and decides to leave with him to make a report. And Lele?

Lele and Alice spend the evening together to celebrate their departure, but he is unable to confess what he feels. But when she finds out from François that Alice is in love with him, she decides it's time to come out.

Lele is eager to see Alice again after her declaration at the airport, but a letter she sent seems to cast a shadow over the future of their relationship. What will happen? Lele goes to the airport for Alice's arrival, but in his place arrives a woman Alice met in Africa and to whom she gave her ticket. The two lovers still have to wait, but what will happen when the time comes?

Lele decides to give Alice the ring he bought her some time ago, but it seems to have disappeared into thin air. Meanwhile, the relationship between Cettina and Giacinto seems definitively over. It's Lele's birthday, but the whole family pretends to forget about it so they can throw him a party. Meanwhile, the doctor's relationship with Alice is kept secret, but how long will they be able to live in hiding?

Libero wants Lele to marry Alice, but his son doesn't feel ready yet. Er Pasticca, a friend of Alberto's, asks him to deliver some pills, but they end up in Annuccia's hands. Alice has planned a romantic weekend with Lele, but he has to go to a conference in Turin. Among the colleagues will be an old friend of Lele's, of whom Alice is terribly jealous.

Cettina asks Giacinto to meet to clarify their situation, but he doesn't show up after being stabbed. Cettina can't know this and assumes her ex deliberately didn't show up. While at Alice's house, Lele learns that his girlfriend has been receiving calls from a manic admirer for several weeks, and he doesn't seem to want to stop there.

Libero enters a contest to win a dinner with a singer, introducing himself as "Henry Killed Spider-Man." His grandfather takes home the prize: Max Pezzali arrives at the Martini house. While the Martinis are on the radio, Lele receives a phone call telling him that Alberto has been in a car accident. Everyone rushes to the hospital and discovers a very different reality.

Alice spends more and more time at Casa Martini. Alberto feels responsible for the accident that left his friend Adriano disabled, but thanks to his uncle's help, he finds the strength to visit him in the hospital. Lele and Alice have decided to get married and are looking for a place for their honeymoon together. Everyone helps them find it, but each has their own opinion, and in the end they decide to make do on their own.

As preparations for Lele and Alice's wedding are underway, Alice is plagued by doubts. Lele finds a letter in which she expresses her confusion and wishes to think things over, far from him.

A group of girls dressed as odalisques show up at Lele's bachelor party, including one who looks very similar to Lele. Alice catches him red-handed, but are we sure she's right? The wedding preparations seem never-ending. The village where Alice spent her childhood vacations is chosen for the wedding ceremony. But there are plenty of setbacks.

Lele and Alice are finally married, but as they're leaving for their honeymoon, she has a miscarriage, unaware she's pregnant. Their plans change dramatically. Maria and Reby have a great idea: have their friends play music in the garage! Will they manage to get Lele's permission? Giacinto plans to quit his job as a security guard and open a shop. Will Cettina allow it?

"Pasticca" apologizes to Adriano, but will she be able to earn forgiveness? To escape Carmelo, a very persistent suitor, Enrica takes refuge in the Martini house. What will Lele and Alice come up with to get some alone time?

Alice feels constantly sick, and a few people are already telling her that she has all the symptoms and might be pregnant. Lele, however, fears something serious. Alice has an ultrasound and discovers she's expecting twins. Lele and Alice return home to tell the others the news when a phone call comes in informing Grandpa Libero that his friend Fausto is in the hospital.

Grandpa Libero packs his bags and leaves home due to his two children's constant arguments, ending up in a nursing home. Until he learns he's been appointed building manager. Nilde wants Lele to go into the delivery room, but the next day Lele wakes up late and arrives at the hospital after his sister has already given birth, to a surprising black baby boy.

Alice and Lele announce the gender of their unborn children to their family: a boy and a girl, but the happiness isn't shared by the entire family because Annuccia becomes jealous. Alice is very anxious about the arrival of the twins, and bombards the family with advice and readings from birth manuals. Not to mention the contractions that terrify her and force the couple to rush to the hospital every night.

Alice tries to help Maria, who is going through a difficult time in her life: Roberto has asked her to make love to him, but the girl doesn't feel ready for such a big step, even if telling him is difficult.

A great job opportunity for Alice is ruined when contractions begin. Meanwhile, Lele is in the hospital where Giorgi died from post-operative rejection... Will he make it in time for the twins' birth?

Lele and Alice are finally married, but while they are leaving for their honeymoon, the woman has a miscarriage, not even knowing she is pregnant. Plans change dramatically.

Maria and Reby come up with a really good idea: to have their friends play in the garage! Will they be able to get Lele's permission? Giacinto thinks of leaving his job as a security guard and opening a shop. Will Cettina allow it?

"Pisticca" apologizes to Adriano, but will he be able to make up for it? To escape Carmelo, a very insistent suitor, Enrica takes refuge in the Martini house. What will Lele and Alice come up with to stay alone for a while?

Alice feels bad all the time and already a few people tell her that the symptoms are all there and that she could be pregnant. Instead, Lele fears that it is something serious.

Alice does the ultrasound and discovers that she is expecting twins. Lele and Alice go home to announce the news to the others, when a phone call arrives letting Nonno Libero know that his friend Fausto is in the hospital.

Nonno Libero packs his suitcase and leaves home due to the constant quarrels of his two children, who find him in a rest home. Until he learns that he has been appointed condominium administrator.

Nilde wants Lele to enter the delivery room, but the next day Lele wakes up late and arrives at the hospital when her sister has already given birth, by surprise, to a black baby.

Alice and Lele announce the sex of the unborn children to the family: they will be a boy and a girl, but the happiness is not shared by the whole family because Annuccia becomes jealous.

Alice is very anxious about the arrival of the twins, and fills the family with advice and reading manuals on birth. Not to mention the contractions that terrify her and force the couple to rush to the hospital every night.

Alice tries to help Maria who is facing a particular moment in her life: Roberto has asked her to make love with him, but the girl doesn't feel ready for such an important step, even if telling her is difficult.

A great job opportunity for Alice is ruined when contractions begin. Meanwhile Lele is in the hospital where Giorgi died from a post-operative rejection... Will he be able to arrive in time for the birth of the twins?

Lele leaves for Australia while Alice, who will soon join her husband, is in Brazil. At university, Maria meets Guido, a brilliant doctor who is looking for a place to live and will be hired by the new director of the local health authority. Maria is fascinated by Guido, but the doctor seems completely uninterested in her. Meanwhile, Ciccio, after a prank that nearly ended in tragedy, attempts to escape from Lele in Australia.

Enrica notices the growing connection between Maria and Guido and puts a "flea in Grandpa Libero's ear," who begins to worry. Meanwhile, everyone begins to discover that Alberto hasn't even passed a single university exam. Grandpa Libero doesn't want anything to happen between Guido and Maria and does everything he can to keep them apart. Meanwhile, Alberto is depressed and sleeps in the garage to be alone. It will take his family's help to pull him out of this dark depression.

Cettina sets out to find Giacinto, discovering a bitter truth. Maria, due to a painful experience, no longer wants to take her medical tests. Will Guido be able to convince her otherwise? Nilde is forced to close the restaurant due to a poisoning and notices that Guido is the one signing the complaint. Alberto, improvising a late-night radio show, manages to get a permanent job.

A new nutritionist, Carlotta, arrives at the local health authority. Her obsessive and aloof behavior fails to win her affection, and misunderstandings and disagreements arise between her and Guido. Until something brings them together again.

Guido tries to befriend Carlotta, but the obstacle he has to overcome is her phobia of physical contact, a difficult obstacle to overcome. Meanwhile, Maria is increasingly jealous of Guido.

Grandpa Libero meets Antoinette, the nanny of one of Annuccia's classmates; the child is strangely too quiet, and Antoinette doesn't understand why, so Grandpa Libero invites her to take him to the local health authority so Guido can examine him. A mysterious statue found in the garden divides the family. Guido tries to help Carlotta solve her problem, but the situation quickly escalates, verging on disaster.

Carlotta confesses to Guido that she's in love with him, sending him into a crisis because he can't understand his feelings for Maria. Their birthday dinner, however, is cancelled due to an unexpected event. Maria is delighted to have met Gianluca, a charming lawyer who courts her like a true princess. Meanwhile, at Ciccio's school, some kids break in at night and break the pipes to skip tests and homework.

Gianluca surprises Maria by taking her to lunch on a boat on the Tiber, bearing a flag with the word "Maria" written on it. Meanwhile, Guido has started dating Carlotta, and everything seems to be going well... or not? Carlotta suggests that Guido move in together, and the doctor accepts. Meanwhile, Maria, having broken off her relationship with Gianluca, has begun volunteering at a drug rehabilitation center.

Maria is preparing for an exam and is very nervous, and Grandpa Libero thinks it's Gianluca's fault. Guido and Carlotta continue their relationship, even though the breakup puts a strain on their relationship. Grandpa Libero hears the news on the news that a young blonde student has been arrested in Fiumicino along with Gianluca for drug dealing. Thinking it's Maria, he feels ill and suffers a heart attack.

Meanwhile, Guido is having problems with Carlotta, who's fed up with seeing her boyfriend completely absorbed in the Martini family. Maria sees Gianluca in front of her house, telling her he wants to run away to avoid the trial. Guido and Carlotta are increasingly at odds, and they argue again during dinner. Guido goes to a friend's house, who introduces him to two girls, and the next morning, the doctor wakes up drunk next to one of them.

Maria is angry with Guido and disappointed because he cheated on Carlotta. A self-esteem course is being held at the local health authority, and thanks to it, the doctors are able to talk about their problems, especially Carlotta's. Guido and Maria go to pick up Annuccia at the zoo, but the little girl gets lost. Because of this, Guido doesn't show up for his appointment with Carlotta, but in the meantime, Maria and the doctor finally kiss.

After their kiss at the zoo, Guido realizes he has strong feelings for Maria, but she wants him to leave Carlotta first. Meanwhile, Carlotta seems increasingly attached to Marcello, and not just for work. Maria is tired of waiting for Guido and decides to go out and distract herself with Reby. During a night out, she's stopped by the police and her car is confiscated. Who will get her out of this mess?

Maria and Guido go to the beach to be alone, and when they return home, covered in sand, Libero realizes they spent the afternoon together. Due to a mistake, Guido is suspended from the local health authority. Maria asks Nonno Libero not to tell anyone about her affair with Guido, but he realizes that everyone already knew. Meanwhile, Guido makes house calls, and patients show up at the Martini house because they want only him.

Guido and Maria's relationship falls apart due to a misunderstanding. Even Grandpa Libero is furious with the boy, unable to understand that it's not actually his fault. Guido then decides to make a video to explain everything. Given all hope of getting Maria back, Guido requests an immediate transfer to Milan and says goodbye to Marcello and Carlotta outside the local health authority. On the way to church, Maria realizes she wants Guido and runs to the station...

Maria is preparing for an exam and is very nervous and Nonno Libero thinks it is Gianluca's fault. Guido and Carlotta continue their story, even if the failed cohabitation puts the relationship to the test.

Nonno Libero picks up the news on the news that a young blonde student has been arrested in Fiumicino together with Gianluca for drug dealing. Thinking it's Maria, he feels bad and suffers a heart attack.

Meanwhile, Guido has problems with Carlotta, tired of seeing her boyfriend totally taken by the Martini family. Maria sees Gianluca in front of her house who tells her he wants to escape to avoid trial.

Guido and Carlotta are increasingly in crisis and during a dinner they argue again. Guido goes to a friend's house who introduces him to two girls and the following morning, the doctor wakes up drunk next to one of the two.

Maria is angry with Guido and disappointed because he betrayed Carlotta. A course on self-esteem is held at the ASL and thanks to it the doctors are able to bring out their problems, especially Carlotta.

Guido and Maria go to get Annuccia from the biopark, but the little girl gets lost. Because of this, Guido does not show up for the appointment with Carlotta, but in the meantime Maria and the doctor finally kiss.

After the kiss at the biopark, Guido understands that he has feelings for Maria but she would like him to leave Carlotta first who, in the meantime, seems increasingly tied to Marcello and not just for work.

Maria is tired of waiting for Guido and decides to go out and have fun with Reby. During a night outing she is stopped by the police and her car is withdrawn. Who's gonna get her out of that mess?

Maria and Guido go to the beach to be alone and when they return home, covered in sand, Libero understands that the two have spent the afternoon together. However, due to an error, Guido is suspended from the ASL.

Maria asks Nonno Libero not to tell anyone about her affair with Guido, but he realizes that in reality everyone already knew. Meanwhile, Guido makes home visits and the patients show up at the Martini house because they only want him.

The story between Guido and Maria falls apart due to a misunderstanding. Even grandfather Libero is furious with the boy, he can't understand that in reality it's not his fault. Guido then decides to make a video to explain everything.

Having lost all hope of getting Maria back, Guido asks for an immediate transfer to Milan and outside the ASL he says goodbye to Marcello and Carlotta. During the journey to the church, Maria realizes that she wants Guido and she runs to the station.

There's a lot of news in the Martini household: Maria and Guido have been engaged for two years, and Guido travels back and forth between Rome and Milan. Ciccio still plays rugby and is engaged to an English girl named Emma and... Grandpa Libero is called to school because Annuccia wrote a decidedly strange essay about family. Maria rents a house for herself and Guido, but discovers that, for now, he's forced to stay in Milan.

Meanwhile, Guido is sad because he has to stay in Milan for another two years and doesn't know how to tell Maria, who is currently interning at the local health authority. On the way to Milan, he has an accident. Maria misses Guido greatly and is considering continuing her studies in Milan, at least until graduation. Guido, meanwhile, is trying every way to get a transfer, but it seems hopeless.

Cettina and Torello's house is now finished, but Cettina is in for some unpleasant surprises. Maria and Guido have decided to move in together, and to keep them from moving far away, Cettina finds an unexpected solution. The family decides to give Guido and Maria a hot tub and a Bohemian crystal chandelier, but the children get angry because they want to furnish the house themselves. The first arguments arise.

Among friends and family, Guido and Maria can't find a moment of peace at home, and this certainly isn't good for the couple. Grandpa Libero, however, due to a series of misunderstandings, thinks Ciccio is taking drugs. Grandpa Nicola makes a grand comeback, but the reality is very different from what he pretends. He invites Maria on a cruise, and she, who initially refuses, eventually realizes that all her grandfather has left is family affection.

While Marcello feels attracted to Eufrasia, Torello's nephew arrives in Rome, whom Cettina welcomes like a son. Cettina asks Torello to bring his grandson Rosalbo into the partnership, but one night they overhear him plotting against them on the phone. The two decide to make life impossible.

Cettina doesn't know how to tell Torello that she's not actually pregnant because he's showering her with attention, arranging everything for the future baby. During an ultrasound, she steals a video showing triplets to play along. Libero is worried about Olindo, an old friend of his who's been missing for days. He learns that he's in a nursing home and can't even talk to him or find out how he's doing. Libero then asks Guido to do an inspection.

Maria has returned from her cruise, and Guido immediately showers her with affection, so much so that the entire Martini family catches them soaking in the hot tub. Meanwhile, Cettina has a truly horrifying experience. Guido is anxious because he has to present the project for the family hospital, but Maria forgets the interviews with the local health authority. But the troubles aren't over: her scooter doesn't work, and it's a race against time.

Reby tells the Martinis that she's getting married to a Japanese designer she met the week before. Maria isn't convinced, knowing her friend's quick crush, but this time it seems serious. Guido finds a pregnancy test, actually belonging to Reby, and, frightened by something he feels is bigger than him, runs away and leaves a note for Maria. Having heard nothing from him for two days, Maria is heartbroken.

A man very similar to Grandpa Libero has been wandering around the Martini house for a few days, and trouble begins for Grandpa: everyone is starting to think he's seriously getting old and can't remember things. After a check-up recommended by Enrica, Grandpa Libero learned that his blood pressure isn't good and that he might need open-heart surgery.

Libero writes a letter and gives it to Enrica, asking her to pass it on to Lele in case he dies. Then they both go to the town hall to sign the wedding papers and ask to get married as soon as possible. The local health authority (ASL) is in danger of closing, and all the doctors organize a sit-in protest, which proves futile. Guido, however, decides to request a return to Milan, since staying in Rome no longer makes sense to him.

While the local health authority (ASL) is being dismantled, the doctors decide to perform all scheduled visits free of charge. Meanwhile, Guido is nervous and has an argument with Maria. Furthermore, he will be responsible for closing the local health authority (ASL) for good. Franco decides to take Maria to a farm, but that same evening, after reading a note from Guido, Maria realizes she's confused. Fortunately, the only thing she's certain of is that she doesn't love Franco.

Guido is seeking funding for the family hospital and decides to organize a charity match to raise funds, while also offering a donation to the bank. After spending the night with Guido, Maria runs away and confides in Reby, telling her friend what happened the night before. She also tells her that she's confused and doesn't know what she's feeling right now.

Guido and Maria are back together and are stronger and happier than before, but he doesn't want Maria to leave for Nigeria. He also has a very important proposal in store. After three years away, Lele returns to the Martini household, finding the situation more than a little unsettling. Thanks to Grandpa Libero's help, Lele will finally be able to become a full-fledged family man again.

Guido is anxious because he has to present the project for the family hospital, but Maria forgets the interviews with the ASL. But the troubles aren't over: the scooter doesn't work, it's a race against time.

Reby tells the Martinis that she is getting married to a Japanese designer she met the week before. Maria is not convinced, knowing the fast falling in love with her friend, but this time it seems serious.

Guido finds a pregnancy test, actually belonging to Reby and, frightened by something he feels is bigger than him, he runs away and leaves himself a note for Maria. The girl, with no news from her for two days, is heartbroken.

A man very similar to grandfather Libero has been wandering around the Martini house for a few days and for grandfather trouble begins: everyone begins to think that he is seriously getting old and does not remember things.

After a check-up recommended by Enrica, grandfather Libero learned that his values ​​are not good and that open heart surgery may be necessary.

Libero writes a letter and delivers it to Enrica with the task of sending it to Lele in case he dies, then both go to the town hall to sign the marriage papers and ask to get married as soon as possible.

The ASL risks closing and all the doctors organize a protest sit-in, which will prove to be useless. Guido, on the other hand, decides to make a request to return to Milan, given that staying in Rome no longer makes sense for him.

While the ASL is being dismantled, the doctors decide to carry out all the visits on the list for free. Meanwhile Guido is nervous and has an argument with Maria. Furthermore, he will be responsible for definitively closing the ASL.

Franco decides to take Maria to a farmhouse, but the same evening the girl, after reading a note from Guido, realizes she is confused and luckily the only thing she is sure of is that she doesn't love Franco.

Guido is looking for funding for the family hospital and decides to organize a heart game to raise funds and at the same time proposes a donation to the bank.

After spending the night with Guido, Maria runs away and confides in Reby, telling her friend what happened the night before. But she also tells her that she's confused that she doesn't know what she's feeling right now.

Guido and Maria are back together and are stronger and happier than before, but he wishes Maria would not leave for Nigeria. He also has a really important proposal in store.

After three years of absence, Lele returns to the Martini house, finding a situation that is not a little indifferent. Thanks to the help of Nonno Libero, Lele will finally be able to become a full-fledged family man again.

Lele has moved to Paris, along with Alice and the twins. Guido is still in Africa with Maria. Meanwhile, Dr. Emilio Villari arrives at the Martini household, in Rome to open a new private clinic. Alberto returns to live with the Martini household, and the family realizes his relationship is over. Cettina continues to be overprotective of her son Eros, to the point of being unable to bear the thought of sending him to kindergarten.

The Martini family meets their new Indian neighbor. After initial hesitation, Ciccio and Annuccia become friends with their grandchildren. Meanwhile, Poggiofiorito is becoming an independent municipality, and it's time for Grandpa Libero to run for office. Grandpa Libero is busy campaigning against lawyer Ulmi, who counts Grandma Enrica among his supporters. The campaign is relentless, culminating in a televised face-to-face.

Grandpa Libero can't stand the commotion outside the Indian restaurant and wants to close it down. All the women are rebelling because they've started attending a yoga class organized by Kabir. Alberto receives a letter from someone who arranges to meet him at the mall, and he thinks it's his ex... Cettina is increasingly drawn to Kabir and confesses to Grandpa Libero that she can't stop thinking about him.

Alberto tells Ciccio he saw Maria, but his cousin doesn't believe him. Grandpa Libero and Torello also say the same. The decisive confirmation will come at Annuccia's recital, where her sister will be among the spectators. Maria goes to visit Annuccia at night, leaves her a drawing, and runs away, but the little girl wakes up and calls her grandparents. Libero chases after the girl, who finally no longer has to hide. But she appears greatly changed.

Cettina lives separately with Torello. Meanwhile, Alberto and Ciccio visit Maria, but she seems determined to get rid of them quickly. She confesses she wants to forget the two years she spent in Africa. Grandpa Libero visits Maria and tries to convince her to return home, but she still isn't ready. But an unexpected event will change her mind.

After being summoned by his fiancée's father, Emilio must return to Turin permanently. During dinner with Sarita, the two believe they will never see each other again, and so, with a kiss, passion ignites. Emilio declares his love for Sarita, but she fears they will end up hurting each other. Meanwhile, Torellhonor appears to be bankrupt, while Maria decides to apply for a job as a waitress at an Indian restaurant.

Torellhonor is on the verge of bankruptcy. Meanwhile, Sarita and Emilio, after convincing an Indian couple not to have an abortion, decide to open a counseling center for non-EU women. Cettina is forced to remove Eros from the expensive private daycare center and place him in a public one. Alberto discovers that his father has cancer and only has a few months to live.

Alberto discovers that chemotherapy hasn't had the desired effect on his father. He nevertheless decides to indulge his father's wishes, wishing to live out his remaining time peacefully. Cettina asks the Martinis for hospitality. A huge party is held at the Indian restaurant. Ciccio, Annuccia, Saju, Sarita, and Maria volunteer as dancers and liven up the evening. Maria is elected "Queen of the Party" and finally confides her secret to Sarita.

Ciccio and Miranda decide to run away and take refuge in a farmhouse in the countryside, owned by the parents of a mutual friend. Everyone is worried, but thanks to little Eros's intuition, Grandpa Libero knows where to look. At the outpatient clinic, everyone is gathered waiting for the announcement of who will be fired, but everyone is shocked to learn that Emilio has submitted his resignation to save his colleagues.

Sarita accepts Emilio's marriage proposal, but Indian tradition dictates that the groom go to the bride with his parents and ask her family for her hand in marriage. Libero and Enrica offer to accompany him. Sarita tries to convince Kabir to accept Emilio, but he is opposed, as he values ​​respecting tradition. Sarita then decides to leave home and go to live with the Martinis.

Sarita and Emilio must keep their respective families at bay: Enrica wants to organize a grand wedding, while Kabir wants to organize a traditional Indian party.

To save the clinic, Emilio proposes to buy it with his colleagues and patients, all of whom will own a small share. Meanwhile, bachelor and bachelorette parties are being planned for the future spouses. At the Indian restaurant, Ravi's arrival causes a stir, especially since Kabir doesn't have the courage to reveal that his niece will soon be marrying Emilio. As if that weren't enough, the young man shows up at the clinic to see Sarita.

Maria falls ill with mumps and can no longer defend her thesis, so to avoid the girl waiting another three months, she can't wait to return to Africa with Guido. To resolve the situation, the family comes up with a plan.

Ravi gives the girl a letter from her father, written 25 years earlier, in which he claims to have promised his daughter in marriage to repay him for a theft. She refuses to marry him, so Ravi demands that she pay the debt. Sarita has decided to marry Ravi. Maria lets Emilio know why the young Indian woman left him. Emilio visits Ravi at his hotel and attacks him. Maria finally manages to defend her thesis and graduate with a top grade.

Alberto discovers that chemotherapy has not had the desired effect on his father. However, the boy decides to indulge him in the desire to live peacefully the time that remains to him. Cettina asks the Martinis for hospitality.

Big party at Indian restaurant. Ciccio, Annuccia, Saju, Sarita and Maria offer themselves as dancers and enliven the evening. Maria is elected "Queen of the party" and finally confides her secret to Sarita.

Ciccio and Miranda decide to flee and take refuge in a farmhouse in the countryside, owned by the parents of a mutual friend of theirs. Everyone is worried, but thanks to the intuition of little Eros, Nonno Libero knows where to look.

At the outpatient clinic they are all gathered to wait for the announcement of who will be fired, but everyone is amazed to read that Emilio has resigned to save his colleagues.

Sarita accepts Emilio's marriage proposal, but Indian tradition requires the groom to go to the bride with his parents and ask her family for her hand. Libero and Enrica offer to accompany him.

Sarita tries to convince Kabir to accept Emilio, but he is against it because according to his mentality it is very important to respect the traditions. The girl then decides to leave her house and goes to stay with the Martinis.

Sarita and Emilio have to keep the intrusiveness of their respective families at bay: Enrica would like to organize a big wedding, while Kabir a traditional Indian party.

To save the clinic, Emilio proposes to buy it with colleagues and patients, all becoming owners of a small share. Meanwhile, stag/hen parties are organized for future spouses.

Ravi's arrival at the Indian restaurant creates confusion, also because Kabir doesn't have the courage to reveal to him that his niece will soon marry Emilio. As if that weren't enough, the young man shows up at Sarita's clinic.

Maria falls ill with mumps and can no longer discuss the thesis to prevent the girl from waiting another three months, since she can't wait to go back to Africa to see Guido. To resolve the situation, the family makes a plan.

Ravi gives the girl a letter from his father, written 25 years earlier, in which he claims to have promised his daughter in marriage to repay him for a theft. She refuses to marry him, so Ravi orders her to pay off her debt.

Sarita has decided to marry Ravi. Maria lets slip with Emilio the reason why the young Indian left him. The latter goes to the hotel to Ravi and assaults him. Maria finally manages to defend the thesis and graduate with 110.

Many returns to Casa Martini: Guido has returned from his experience in Africa, Lele returns with his twins. Cettina and her family are absent: the Martini family's former housekeeper has apparently disappeared in a shipwreck. A nasty surprise awaits Guido and Maria: they discover that their apartment's tenant refuses to return the keys. During a chat, Grandpa Libero reveals to Lele that he's feeling the weight of old age.

With Grandpa Libero gone, Lele is left to care for the entire family. Elena and Bobò are anxious about their first day of school. Annuccia continues to behave rather arrogantly toward her younger siblings. Maria is assigned the case of a little girl hospitalized for stomach pains, likely due to her grandfather's absence, who has gone on a long trip. Maria discovers that the truth is much more painful.

Fanny and Maria become friends, but Maria is jealous because she fears Fanny is courting Guido. She doesn't suspect that her young colleague is interested in another member of her family: her father. Maria's pregnancy progresses, and so do the cravings. Meanwhile, a child neuropsychiatry department will be opened at the clinic, which is precisely the young doctor's specialty.

Libero and Enrica return from Puglia for the Christmas holidays. Meanwhile, Guido resists the idea of ​​starting a relationship with his newly reunited mother. Fanny discovers toxic waste dumped in a river. Guido and Ave have a tough confrontation, and Ave increasingly feels the pain of not being there when they needed her. Giulio wins the lottery, and an unexpected snowfall in Poggiofiorito brightens Christmas Day.

Maria prepares an exclusive evening for herself and Guido, who is forced to stand her up. She's felt a bit left out of Guido's life since she's expecting a baby, and she's convinced he no longer likes her since she's pregnant. As Maria's final months of pregnancy approach, Lele senses that becoming a grandfather will be a new adventure, completely different from being a father. Especially since Maria's water breaks early!

Grandpa Libero returns to Rome to meet little Paola. Lele tries to convince Fanny not to continue the relationship, but she's truly in love. Giulio convinces Grandpa Libero to participate in a new program, Cambio Nonno (Grandpa Change). Libero accepts and finds himself with a new family, one from Lazio, to boot. Consequently, the grandfather of that family goes to live with the Martinis.

The twins notice the silhouette of a woman behind the window of the Torello house and believe it to be Cettina's ghost. Grandma Enrica, with her friends, organizes a séance to summon her. A friend of Annuccia's surprises Fanny and Lele. Annuccia, after finding out from her friend, is reluctant to accept her father's new girlfriend, unlike the rest of the family, who are still somewhat confused.

A colleague confesses to Lele that he's in love with Fanny. Lele, embarrassed, doesn't reveal his relationship with the girl. Meanwhile, Ave tells Guido that his sister hasn't taken the news of having a brother well. The twins convince Bianca and Lele to go to the water park, where they hope to make them fall in love. Fanny decides to tag along to get to know the twins, but they're having a hard time.

Fanny decides to introduce Lele to her family. Ave receives permission from the Martinis to move into their home, as the housekeeper Melina is unable to care for the baby alone. Bianca receives a commission from the Vatican to make a chocolate sculpture, but the twins smash it to pieces. Lele helps Bianca, and after working all night, the two kiss.

Lele discovers that Fanny's tests were switched, meaning she isn't pregnant. The two decide to break up, and Lele can now live with Bianca, but Bianca is about to return to the Netherlands. The Martini family is summoned by the police because an American woman is asking for them. The Martinis discover that the woman is actually Cettina, although she seems to remember nothing of her past.

Lele tries, in vain, to reconnect with Bianca, who is hurt by the doctor's treatment. She felt seduced and abandoned because of Fanny's pregnancy, and it's difficult to forgive. Maria believes Guido is cheating on her with Albina, unaware that she is his sister. Lele makes one last attempt to win Bianca back, but it's too late: she must leave for the Netherlands.

The Martini family organizes a surprise birthday party for Lele, who is desperate for the woman he loves. Ciccio learns that Tracy has returned to Rome. He can't resist: he goes to visit her at the riding stables! Guido confesses his betrayal to his wife, who packs her bags and goes to live alone with her daughter, driving Guido into despair. Ciccio realizes he's in love with Tracy. Meanwhile, Lele goes to London and declares his love for Bianca.

Guido tries to win Maria back, but when she seems to have forgiven him, she sends him a request for separation. Lele intends to stay in Rome forever and announces this to his family, who are thrilled. Grandpa Libero and Ciccio's double wedding is approaching, and preparations are in full swing. Maria and Guido must meet with their lawyer for a preliminary meeting to discuss the separation. But will it be the right choice?

A friend of Annuccia surprises Fanny and Lele. Annuccia, after finding out from her friend, doesn't accept her father's new girlfriend, unlike the family who are still a bit confused.

A colleague confesses to Lele that he is in love with Fanny. Lele, embarrassed, does not reveal that he is having an affair with her girlfriend. Meanwhile, Ave tells Guido that her sister did not take well the news of having a brother.

The twins convince Bianca and Lele to go to the Aqua Park, where they hope to make them fall in love. Fanny decides to follow them to get to know the twins well, but they really don't want to know.

Fanny decides to introduce Lele to her family. She has received permission from the Martinis to move into their house, because the maid Melina is unable to look after the child alone.

Bianca receives from the Vatican the task of preparing a chocolate sculpture, but the twins reduce it to crumbs. Lele helps Bianca and, after working all night, the two kiss.

Lele discovers that Fanny's analyzes have been switched and therefore the girl is not pregnant. The two decide to break up and now Lele can stay with Bianca, but the latter is about to return to the Netherlands.

The Martini family is summoned by the police because an American woman asks about them. The Martinis discover that the woman is actually Cettina, even if she seems to remember nothing of her past.

Lele tries, in vain, to get closer to Bianca, hurt by how she was treated by the doctor. She has felt seduced and abandoned by Fanny's pregnancy, and it is hard to forgive.

Maria believes that Guido is cheating on her with Albina, without knowing that she is his sister. Lele makes one last attempt to win Bianca back, but it's too late: she, the latter has to leave for the Netherlands.

The Martini family organizes a surprise birthday for Lele, desperate because he thinks of the woman he loves. Ciccio learns that Tracy has returned to Rome. She can't resist: he goes to see her at the stables!

Guido confesses the betrayal to his wife, who packs her bags and goes to live alone with her daughter, making Guido desperate. Ciccio understands that he is in love with Tracy. Meanwhile Lele goes to London and declares her love for Bianca.

Guido tries to win Maria back, but the girl, when she seems to have forgiven him, sends him a separation request. Lele intends to stay in Rome forever and announces it to the family, who are enthusiastic about it.

The double wedding of Nonno Libero and Ciccio is upon us and preparations are underway. Maria and Guido have to meet the lawyer for a preliminary interview, to talk about the separation. But will it be the right choice?

Three years have passed since Guido's death, and the time has come for Maria to start over, even romantically. Meanwhile, Lele asks Bianca to take the plunge, but he discovers she's still married to her ex-husband. Bianca is determined to divorce him so she can marry Lele, who has since reunited with an old acquaintance, Virginia, while researching a rare disease. Furthermore, Annuccia faces trouble.

Bianca finds herself struggling on two fronts: seeking information about her ex-husband, and jealousy over Virginia, which grows despite Lele's reassurances. Maria receives a tempting job offer. Marco announces on the news that Nonna Enrica's D.O.P. mozzarella from Puglia is made with a different type of milk, not buffalo milk. The war begins!

Lele teaches a lesson on the environment at Annuccia's school and becomes a hit with his daughter's classmates. Meanwhile, Bianca's ex-husband, trying to put a spoke in her wheels, is determined to win over little Inge by any means necessary. A bolt from the blue strikes Bianca: the chocolate shop has been put up for sale. Furious and fearful for the future, she finds herself weighing her ex-husband Gus's offer. Meanwhile, Grandma Enrica plots to bring Maria and Marco closer together.

The Martini children are being bullied at school. When Lele and Bianca discover the situation, they convince the children to report the incident to their teacher. Bobò will be the one to demonstrate all the necessary courage. Lele's jealousy leads him to follow Bianca, who has left for the countryside with Gus and the children. Meanwhile, Maria helps Marco expose a clandestine gambling den.

Maria, with the help of her entire family, takes care of her little Palù and returns to work at the clinic. Grandpa Libero, who has left for America, entrusts Grandma Enrica with running the Apulian food products business. A hot air balloon ride offered by Gus turns into a cauldron of tension. Lele joins them as soon as he can, just in time to see the engagement ring he gave Bianca fall from the sky.

Grandma Enrica returns from the United States with a surprise that leaves everyone stunned: she's taken in a homeless man who leaves the whole family stunned. The Martinis' Christmas dinner is, as always, a seaport. And this year, on the day when everyone is at their best, Lele will give Gus a break.

Lele, due to the presentation of the research for the drug he's working on, is spending more and more time with his colleague Virginia. Virginia's ex-boyfriend, increasingly jealous, continues to harass the doctor. Maria feels guilty for not having devoted enough time to Marco lately. But when he shows up unexpectedly at her house, she'll be the one left speechless.

Ciccio is faced with a difficult realization: Tracy doesn't want to get pregnant because of the competitions she has to complete. Meanwhile, Maria doesn't believe Marco's explanations. Inge is willing to do anything to spend her father's birthday at the farmhouse with him. Despite Bianca's protests, she puts into action a foolproof plan that will cause a lot of problems, including for Lele.

Ave receives an anonymous letter from a woman, in which she learns that Guido's heart has been transplanted into her son's body. Meanwhile, Giulio meets Magalli, to whom he wants to propose a TV show. Both the clinic and the company that produced the drug are reported by the brother of the patient they were treating. Meanwhile, Marco and Maria discover that they truly like each other.

A ministry inspector comes to inspect the clinic after Virginia chooses to administer a drug not yet authorized. Marco receives an unexpected phone call and learns he must leave for Venice. Everything between Maria and Marco is going swimmingly, and passion explodes. Meanwhile, Bianca discovers the truth about her divorce from Gus at a crucial moment in their relationship.

Lele is determined to take control of his love life, telling Virginia there's nothing going on between them and declaring in front of his children that he'll do anything to win back Bianca, the only woman he loves. The discovery of Bianca's pregnancy deeply upsets her, and she decides to leave. Virginia will seek her out to explain the truth.

Like the baron in the trees, Inge decides to run away from home, just on the day Bianca is busy baking a birthday cake for Maria. The search begins. The search continues, and Gus finally finds his daughter at the farmhouse, suggesting she travel with him to Los Angeles. At the baby's first ultrasound, Lele and Bianca discover that Ciccio and Tracy are also pregnant.

At the Martini household, preparations are in full swing for Lele and Bianca's wedding. Little Palù is tasked with bringing photos of her parents to school, and Maria helps her daughter cope with the grief of Guido's passing. The big day has arrived, and everyone is ready to head to Ovindoli for Lele and Bianca's wedding. But as always in the Martini family, the unexpected is just around the corner. Will they make it?

Maria feels guilty for not having dedicated enough time to Marco lately. But when she shows up at her house by surprise, she'll be the one to be left speechless.

For Ciccio it's time for a hard discovery to accept: Tracy doesn't want to get pregnant because of the competitions to be achieved. Meanwhile, Maria does not believe Marco's explanations.

Inge is willing to do anything to spend her father's birthday at the farmhouse with him. Despite Bianca's remonstrances, she implements an infallible plan, which will cause many problems, even for Lele.

Ave receives an anonymous letter from a woman, in which she learns that Guido's heart has been transplanted into her son's body. Meanwhile, Giulio meets Magalli, to whom he would like to propose a TV format.

Both the clinic and the company that was involved in the production of the drug are denounced by the brother of the patient being treated. Meanwhile Marco and Maria discover that they really like each other.

An inspector from the ministry comes to check the clinic after Virginia chooses to administer an as-yet-unlicensed drug. Marco receives a sudden phone call and discovers that he will have to leave for Venice.

Between Maria and Marco everything goes swimmingly, and passion explodes. Meanwhile, Bianca discovers the truth about her divorce with Gus at a crucial moment in their relationship.

Lele is determined to take over the reins of his love life, making it clear to Virginia that there is nothing between them and declaring in front of his children that he will do anything to get back Bianca, the only woman he loves.

The discovery of a pregnancy deeply disturbs Bianca, who decides to leave. Virginia will look for her to explain the reality of the facts.

Like the rampant baron, Inge decides to run away from home, just on the day when Bianca is busy preparing a birthday cake for Maria. The searches begin.

The searches continue and finally Gus finds his daughter at the farmhouse, proposing to leave with him for Los Angeles. Lele and Bianca at the first ultrasound of the baby discover that Ciccio and Tracy are also pregnant.

At the Martini house, preparations are in full swing for the wedding of Lele and Bianca. Little Palù is given the task of bringing photos of her parents to school and Maria helps her daughter overcome the pain of Guido's disappearance.

The big day has arrived, and everyone is ready to reach Ovindoli where Lele and Bianca's wedding will take place. But as always in the Martini family, the unexpected is just around the corner. Will they make it?

Grandpa Libero has finally returned to Poggio Fiorito. Immediately, Marco and Maria announce their wedding, which will take place in two weeks. For the occasion, Grandpa has a special surprise in store: he's hiring Al Bano! The offer to buy the Aurora clinic forces Lele to tell the truth about the house they're about to take from him. The Martini family, informed, takes action.

The situation is critical for the Martinis. Really risking losing their house, Grandpa Libero sets out to track down the builder who defrauded them. For Grandpa Libero, losing his home is such a serious threat that it's even affecting his health. After his reluctance to sell used items at the neighborhood flea market, the family convinces him that everything is fine.

Lele finds himself clandestinely treating an old patient. He decides, taking great risk, to begin clandestinely seeing patients who can't afford the clinic's excessive prices. Annuccia begins working part-time as a delivery driver rather than ask her father, Lele, for money for the international class trip. She finds herself in a rough neighborhood when some thugs harass her.

Bianca's relationship with her mother deteriorates under the chagrined eyes of Inge, who is truly devoted to her grandmother. Meanwhile, Marco lies to Maria about his new assignment. As if they weren't already in enough trouble, the Martinis have to renovate the roof of their house. It's not exactly the right time financially, and the family is truly worried.

Lele and Bianca discuss the matter and believe it's necessary to fire the gardener, who has been tending the villa's garden for years. However, Melina, overhearing the conversation, believes she'll be the one to be fired. So she immediately gets to work. Marco returns to Rome, and Maria picks him up at the airport. Unexpectedly, his colleague Antonia is also with him. Lying to his girlfriend once again, Marco manages to get away with it, but Maria begins to suspect him.

Lele and Bianca discuss the future of the Martini household and decide to look for a new place. The children, however, don't welcome the news, and they decide to move into the house, unbeknownst to the entire family. Marco gives Maria his engagement ring and promises that they will get married immediately after his final departure for Brussels. Meanwhile, at Villa Aurora, Lele and Guenda seem to grow closer after she shows her human side.

Maria has no idea where Marco is, so she takes it upon herself to authorize the operation for little Jonathan. She discovers the bitter truth: Marco has been lying to her, continuing to film documentaries in war zones. Marco returns to Rome, and Maria is waiting for him at the airport, only to tell him that it's finally over between them. Once they both return home, the situation seems to improve: but how long will it last?

Things between Marco and Maria seem to be getting worse and worse, so much so that he returns home early in the morning to make the children believe he's still living with them. Grandpa Libero notices the situation and promises to help him. Seeing her father's increasingly sad state, Inge decides to arrange a meeting with the separated mother of a schoolmate. However, the date goes sour, and the woman goes into anaphylactic shock.

Maria seems more determined than ever to pursue a relationship with Roberto, but she continues to hide everything from Marco, who begins to suspect her. Maria and Roberto's relationship seems to be progressing well, but when she discovers that Palù has bitten one of her friends, displaying an aggressive attitude she's never seen before, she realizes the little girl is suffering.

Marco risks losing custody of Jonathan, but Maria offers to help him. The situation becomes more complicated, because now Marco and Maria are forced to organize a fake wedding. With the help of their family, Marco and Maria manage to convince the assistant. Everything could be resolved, if it weren't for Micol's threat: if the wedding doesn't happen, she will do anything to get the child back.

Marco and Maria announce to their children that when they return from the school camp, they will each go their separate ways. At this point, Maria can focus on Roberto and introduce him to the family. While Maria is driving to her daughter's camp, her car breaks down. She decides to call Roberto, but just then Marco arrives and offers to drive her.

Lele helps Maria clear her head, and the young woman realizes that her heart actually beats for Marco. Unfortunately, Roberto's father is on the verge of bankruptcy, and Maria doesn't feel like leaving him now. Antonia does everything she can to distance the journalist from his ex-girlfriend, even making Maria believe that, in addition to moving to New York City, Marco will be living there with her.

Everything seems to be working out for the best: Lele manages to buy back the house with the money he got in Paris thanks to Bianca's show, while Maria, after clarifying her doubts, will return to Marco. And Roberto? As they're about to cut off the electricity and gas at the Martini house, the family decides to leave before it all ends before their eyes. But there's still time to plan a surprise wedding for Maria.

Marco returns to Rome and Maria is waiting for him at the airport, but only to inform him that it is definitely over between them. Both back home, the situation seems to improve: but how long will it last?

Between Marco and Maria it seems to get worse and worse, so much so that he goes home early in the morning to make the children believe that he still lives with them. Nonno Libero notices the situation and promises to help him.

Inge, seeing her father increasingly sad, decides to arrange a meeting with the estranged mother of a schoolmate of hers. However, the appointment falls apart and the woman suffers from anaphylactic shock.

Maria seems more than ever willing to embark on a relationship with Roberto, however continuing to hide everything from Marco, who begins to suspect.

The story between Maria and Roberto seems to continue at its best, but when she discovers that Palù has bitten her friend, showing an aggressive attitude that had never been shown before, she understands that the little girl is suffering.

Marco is in danger of losing custody of Jonathan, but Maria offers to help him. The situation becomes more complicated in this way, because now Marco and Maria are forced to organize a fake wedding.

Marco and Maria with the help of the family manage to convince the assistant. Everything could be resolved, were it not for the fact that Micol threatens them: if the wedding doesn't take place, she will do everything to get the baby back.

Marco and Maria announce to their children that when the two return from the camp organized by the school, each will go his own way. At this point Maria can devote herself to Roberto and introduce him to the family.

While Maria is in the car to join her daughter at the campsite, her car breaks down. So she decides to call Roberto, but just at that moment Marco arrives and offers to accompany her.

Lele helps Maria clear her head and the young woman understands that her heart actually beats for Marco. Unfortunately Roberto's father is on the brink of bankruptcy and Maria doesn't feel like leaving him now.

Antonia does everything to distance the journalist from his ex-girlfriend to the point of making Maria believe that, in addition to moving to New York City, Marco is going to live there with her.

Everything seems to turn out for the best: Lele manages to buy back the house with the money he got in Paris thanks to Bianca's broadcast, while Maria, after having clarified her doubts, will go back to Marco. And Roberto?

As they are about to cut off electricity and gas at the Martini house, the family decides to leave before everything ends before their eyes. But there's still time to plan a surprise wedding for Maria.

Maria and Marco are busy preparing for the wedding of his younger sister, Sara, who is arriving from America. Grandpa Libero and Enrica are also awaiting the arrival of Lorenzo, a surgeon and Libero's nephew. Sara reveals to her brother Marco that she will no longer run competitively. By making up a lie, she covers up the truth: Sara, in fact, also suffers from heart problems. Meanwhile, her wedding gifts are sent back.

It's Elena and Bobò's first day of high school, and both are gripped by their first anxieties and fears. Elena decides to skip school and go to the beach with Tommy, whom she's immediately fallen in love with. Bobò will cover for her. Giada's arrival at the Martini house is like a bolt from the blue. The only one she's spoken to for a while has been Sara, who wants to help in any way she can the girl she rescued on the street.

Sara begins managing the new bar across the street from Casa Martini. On the opening morning, however, a young manager from a chain of aperitif bars, Stefano, shows up and wants to take over the place. Sara is robbed at the bar by two men blackmailing Giada. Lorenzo finds Sara unconscious on the floor and calls an ambulance. At the clinic, the young woman wakes up and learns from Lorenzo that she should have a CT scan.

Grandpa Libero and Grandma Enrica are busy getting Palù and Jonathan vaccinated at the clinic. Stefano takes Sara to his country estate, and the two become very close. Lorenzo is running with Sara, who, overdoing it, ends up feeling ill, given her heart problems. Grandma Enrica and Ave convince Grandpa Libero to go on a diet and take an oriental gymnastics class.

After the night spent together, Lorenzo tells Sara that the situation is difficult and they can't be together. However, the two continue to grow closer, even when they decide to go to the movies separately. Sara and Stefano spend a wonderful day paragliding. Everything turns dark when Sara reveals that, due to a heart defect, she could die at any moment.

A newspaper reports that Marco and a certain Fiamma, an athlete and acquaintance of Sara's, are having a romantic relationship. Maria discovers this, but her husband assures her it's just a journalistic invention. Could it be true? Stefano and Sara spend the night together, but nothing happens between them. However, the young man makes a mistake and finds himself in the living room of the Martini family, with the entire family. He finally gets to meet them!

Marco and Maria discover the whereabouts of Giada's little brother, Daniel. His parents agree on one condition: Daniel must not know that Giada is his sister, nor that he was adopted. Thanks to Maria's help, Giada manages to meet her brother, Daniel. They immediately connect, even though the little boy doesn't recognize his sister. Lorenzo, on the other hand, is very nervous about the operation he has to perform.

Lorenzo and Veronica continue to meet secretly at the hotel. Sara arrives, warning them that Fabio is coming. To avoid arousing suspicion, Sara kisses Lorenzo, and the two pretend to be engaged. Sara and Stefano bring Marco home, but he doesn't remember anything and has even lost his wedding ring. So, his sister and her fiancé decide to investigate. Tommy paints a mural dedicated to Giada.

Fiamma is forced to reveal the truth, saying that nothing happened between her and Marco; he was drunk and kept repeating Maria's name. The two, therefore, make peace...for now. Giada and Tommy decide to run away and escape from everyone. Maria and Marco, having discovered everything, decide to go look for them with the help of Lorenzo and Veronica.

Lorenzo takes his wife to the mountains, to the Majella, to spend time together. But during their vacation, Lorenzo is forced to reveal to Veronica about the night he spent with Sara. Maria can't bring herself to tell Marco she's pregnant, but the situation becomes increasingly exasperating until she is forced to come clean.

Lorenzo remained in Poggiofiorito to care for his uncle, who faked a broken leg, hoping something would blossom between him and Sara. One night, however, the young man dreams of finding himself in a place with him. Lorenzo and Sara have finally decided to force fate and get together. For this reason, the young man decides to leave for America and reveal everything to his wife.

Stefano takes Sara to the clinic, where Oscar tells her that her heart is failing and the only solution is to be admitted immediately for surgery. She decides not to tell Lorenzo. Lorenzo decides to speak to Dr. Savino himself, but he hides behind a medical confidentiality pact. Oscar remains her last resort, and from him she manages to uncover the truth and the illness Sara is suffering from.

A little girl finds Sara unconscious on the beach. She calls Lorenzo on her cell phone, who rushes to her and, after resuscitating her, takes her to Villa Aurora. While Grandpa Libero, Grandma Enrica, and Ave pray for Sara's recovery after the surgery, Lorenzo finds a television on which he can watch a video recorded by Sara before the operation.

Thanks to Maria's help, Giada manages to meet her brother Daniel. Between the two she is immediately understood, even if the little one fails to recognize her sister. Lorenzo, on the other hand, is very agitated about the operation he has to carry out.

Lorenzo and Veronica continue to meet secretly in the hotel. This is where Sara arrives, warning them that Fabio is on the way. In order not to arouse suspicion, Sara kisses Lorenzo and the two pretend to be engaged.

Sara and Stefano take Marco home, but the latter doesn't remember anything and has also lost his wedding ring. For this, her sister and her boyfriend decide to investigate. Tommy draws a mural dedicating it to Giada.

Fiamma is forced to reveal the truth, saying that nothing happened between her and Marco, he was drunk and kept repeating Maria's name. The two, therefore, make peace… for now.

Giada and Tommy decide to flee and get away from everyone. Maria and Marco, having discovered everything, decide to go and look for them with the help of Lorenzo and Veronica.

Lorenzo takes his wife to the mountains, on the Majella, to spend time together. But, during the vacation, Lorenzo will be forced to reveal to Veronica about the night spent with Sara.

Maria fails to tell Marco that she is pregnant, but the situation becomes more and more exasperating until the girl is forced to spill the beans.

Lorenzo remained in Poggiofiorito to assist his uncle, who faked a broken leg hoping that something would arise between him and Sara. One night, however, the young man dreams of being in a place and, with him.

Lorenzo and Sara have finally decided to force fate and get together. For this, the young man decides to leave for America and reveal everything to his wife.

Stefano takes Sara to the clinic and here Oscar tells her that her heart can no longer hold up and the only solution is to immediately go to hospital and undergo surgery. She decides not to say anything to Lorenzo.

Lorenzo decides to speak to Dr. Savino himself, but he is hiding behind professional secrecy. The last beach remains Oscar, from which he manages to discover the truth and the disease Sara suffers from.

A little girl finds Sara on the beach, unconscious. With the girl's cell phone, she calls Lorenzo, who immediately runs to her and, after reviving her, takes her to Villa Aurora.

While grandfather Libero, grandmother Enrica and Ave rely on prayers to ensure that Sara recovers after the operation, Lorenzo finds a television on which he can see a video recorded by the girl before the operation.

While the entire Martini family is on vacation in Puglia, a mysterious man leaves an envelope addressed to Elena, Lele's late first wife, in the mailbox of the Poggio Fiorito villa. Valerio, Elena's former piano teacher, under the pretext of a rap concert, tries to get to know Anna and seems overly interested in the affairs of the Martini household. Meanwhile, Sara, without consulting Lorenzo, signs the preliminary agreement for the purchase of a villa.

Lorenzo learns that the tendon in his hand is damaged and blames Sara for the incident. Mortified, Sara decides to take a walk on the beach. There, by chance, she stumbles upon a party where, over beers, she meets Andrea. Completely drunk, the two end up in bed together. Sara and Enrica decide to track down Dr. Williams, who could operate on Lorenzo's hand, but the doctor is on vacation and refuses to work. The doctor's plans include to tour Rome in a carriage, but a strike prevents him. So Sara and Enrica decide to "steal" one and take him on a tour of Rome. To thank them, Dr. Williams agrees to operate on Lorenzo. Oscar's daughter Agnese returns to her father in the city, but he is busy and can't get to the station, so Tommy goes instead. Libero finds a letter in which Maddalena writes to a certain Francesco and, unaware that he is the Pope, believes that she is in love with the gardener of the parish she attends.

Maddalena is summoned to the Vatican for a private audience with Pope Francis, but Elena and Bobò are behind the summons letter. Anna, meanwhile, continues preparing for the medical school entrance exams, but her encounters with Valerio and Geko become increasingly frequent. Anna, accompanied by her grandparents and the Martini family's lucky teddy bear, takes the medical school entrance exam. Meanwhile, Lorenzo decides to admit Celeste, a young resident, to the operating room, but she panics and runs away.

Libero and Enrica invite Valerio to dinner to repay him. For this reason, Lele is forced to reveal the secret that binds him to the man. Meanwhile, Lorenzo hires Andrea to renovate his new house; when Sara meets him, she remembers the wild night she spent with him. Libero, still reeling from the revelation about Valerio, tries to attack the man, urging him to stay away from Anna. Meanwhile, Emiliano, at the suggestion of Ginevra, his new girlfriend, goes to Lele's clinic to hand over some money he owes to the young Martini, thus breaking all ties with the past.

It's Anna's birthday. To celebrate, young Martini gathers relatives and friends, including Valerio and Geko, at her house. At the end of the evening, Lele confesses the truth about Valerio and the paternity test to Libero, Enrica, Sara, Lorenzo, and Maddalena. Lele is determined to tell Anna the whole truth about Valerio, but he can't find the right moment to broach the subject. Meanwhile, Sara and Lorenzo are invited by Federica, Andrea's wife, to the same beach resort where Sara and Andrea spent their wild night.

Anna, having discovered the truth about her real father, is distraught and decides to lock herself in her room to be alone and reflect. Meanwhile, the Martinis finally decide to build a second bathroom in the house, despite Libero's resistance. Paolo, Bobò's best friend, reveals to Lele and Edoardo that he is gay and is at the mercy of school bullies. Meanwhile, Augusto, a plumber who immediately takes a liking to Maddalena, arrives at the Martinis' house.

Anna is increasingly struggling and has failed her entrance exam. Lele asks Carla to have Anna register for the Biology exam, which, once passed, will allow her to enter medical school. Anna, on the eve of her exam, is spending the night at a nightclub. Tommy and Agnese, who told their parents they were going to a film screening organized by the school, are at the abandoned factory.

To get revenge on Maddalena, Augusto brings his mischievous nephew to the house, who gets up to all sorts of mischief. After discovering Augusto's plot, Maddalena scolds him, but he tells her they're even. Upon learning the truth about Sara's betrayal, Lorenzo punches Andrea. Then he gives in to desperation and gets drunk. Meanwhile, the financiers for the new surgery department, which Lorenzo will direct, arrive at the clinic.

Ciccio returns to Rome to view a mare he wants to buy. He's warmly welcomed by the entire family and goes with Lele to Valerio's loft where Geko's album presentation is taking place. On the plane to Berlin, Sara meets Matteo, a concert promoter who gets her two tickets to a DJ's show. Lorenzo, annoyed by their friendship, tells his wife that something between them is broken forever.

Having learned of Lorenzo's crisis, Libero goes to the house to speak with Sara. She shows Libero a nearby grove, but just then, city gardeners arrive: the trees need to be cut down. Maddalena, deeply concerned about Rocco's situation, decides to go look for him. Libero accompanies her, but when they arrive at the address Maddalena indicated, they find a crowd of people at the door and an ambulance.

Rocco, who has settled into the Martini household, does nothing but eat and then lounge on the couch. When he says he's going to look for a job, Augusto and Libero follow him and catch him playing video poker. Lorenzo manages to operate on a little girl with a heart defect with his. Celeste and Lorenzo are overjoyed and congratulate each other. They leave the clinic together, hand in hand, but Sara catches them red-handed.

Lorenzo spent the night with Celeste. Sara decides to participate in the "Cuore a Cuore" association race, but Lorenzo refuses to sign the eligibility form because he deems Sara's competitive activity too risky. Jacinta goes to Poggiofiorito to meet Rocco and tell him she intends to get back together; Rocco is on the verge of giving in when he notices Libero and Enrica spying on them.

Emiliano leaves the Raggio di Sole Center and finds Ginevra lifeless on the ground after being hit. He calls an ambulance that takes the girl to Villa Aurora, where Lele is informed of her identity. It's the day of the volleyball tournament final. The boys are excited and thrilled, but they realize their coach is distracted and has other things on her mind. Meanwhile, Lorenzo receives a bitter message from Sara.

Anna, on the eve of her exam, is spending the night at a disco. Tommy and Agnese who told their parents they were going to a school film screening, but they are at the abandoned factory.

In order to take revenge on Maddalena, Augusto brings a pestiferous nephew into the house who gets up to all kinds of things. After discovering Augusto's machination, Maddalena scolds him, but he tells her that they are now even and a draw.

Knowing the truth about Sara's betrayal, Lorenzo punches Andrea. Then he gives in to despair and gets drunk. Meanwhile, the financiers of the new surgery department arrive at the clinic, which will be directed by Lorenzo.

Ciccio returns to Rome to see a mare to buy. He is warmly welcomed by the whole family and goes with Lele to Valerio's loft where Geko's record is being presented.

On the plane to Berlin, Sara meets Matteo, a concert organizer who gets her two tickets for a deejay's show. Lorenzo, annoyed by that friendship, tells his wife that something between them is broken forever.

Made aware of the crisis with Lorenzo, Libero goes to the cottage to talk to Sara. The girl shows Libero a nearby grove but just then some gardeners from the Municipality arrive: the trees have to be cut down.

Maddalena, very worried about Rocco's situation, decides to go and look for him. Libero accompanies her, but when they arrive at the address indicated by Maddalena, they find a group of people in front of the door and an ambulance.

Rocco, who has installed himself bag and baggage in the Martini house, does nothing but eat and then lie down on the sofa. When he says he will look for a job, Augusto and Libero follow him and catch him while he is playing video poker.

Lorenzo manages to operate on a little girl with a heart malformation with his own. Celeste and Lorenzo are very happy and compliment each other. They leave the clinic together hand in hand, but Sara catches them in the act.

Lorenzo spent the night with Celeste. Sara decides to participate in the race run by the “Cuore a Cuore” association, but Lorenzo refuses to sign the eligibility form because he considers Sara's competitive activity too risky.

Jacinta goes to Poggiofiorito to meet Rocco and tell him that she intends to get back together with him; Rocco is about to give in when she notices the presence of Libero and Enrica who were spying on them.

Emiliano leaves the Raggio di Sole Center and finds Ginevra lifeless on the ground, after being run over. He calls an ambulance that takes the girl to Villa Aurora, where Lele is informed of the girl's identity.

It's the day of the final of the volleyball tournament. The boys are excited and excited, but realize their coach is distracted and has other things on her mind. Meanwhile Lorenzo receives an embittered message from Sara.