Comedian Chelsea Handler talks about celebrity gossip, pop culture and interviews celebrities while giving her audience something to laugh at. She is accompanied by her round table guests which usually future comedians or E correspondents. She also still has her little assistant Chuy by her side.

Comedian Chelsea Handler talks about celebrity gossip, pop culture and interviews celebrities while giving her audience something to laugh at. She is accompanied by her round table guests which usually future comedians or E correspondents. She also still has her little assistant Chuy by her side.

Sarah Colonna, John Caparulo, Geoffrey Bara

Josh Wolf, Tony Rock, Courtney Friel

, Jason Sklar, Randy Sklar, Sarah Colonna

Heather McDonald, Jeffrey Ross, Tanika Ray

Chris Hardwick, Natasha Leggero, Andrew Daly

Perez Hilton, Guy Branum, Kim Coles

Brad Wollack, Jo Koy, Carrie Keagan

Alonzo Bodden, Chris Franjola, Arden Myrin

Kevin Hart, Billy Gardell, Kristin Dos Santos

Josh Wolf, Hyla Matthews, Perez Hilton

Natasha Leggero, Ben Gleib, Jen Kirkman

Jo Koy, Kirk Fox, Whitney Cummings

Sarah Colonna, John Caparulo, Todd Glass

Loni Love, Heather McDonald, Ross Mathews

Chris Franjola, John Caparulo, Jen Kirkman

Jo Koy, George Wallace, Ken Baker

Michael Yo, Brad Wollack, Michelle Biloon

Megyn Price, Josh Wolf, Guy Branum

John Caparulo, Elon Gold, Ashlan Gorse

Lavell Crawford, Heather McDonald, Ross Mathews

T.J. Miller, Loni Love, Dave Hanson

Jordan Rubin, Josh Wolf, Sarah Colonna

John Caparulo, Tony Rock, Whitney Cummings

Justin Tranter, Josh Wolf, Donnell Rawlings

Randy Sklar, Jason Sklar, Michael Yo

Josh Wolf, Donnell Rawlings, Justin Tranter

Rob Schneider, Ben Gleib, Heather McDonald, Ross Mathews

Ross Mathews, Jen Kirkman, Greg Proops

Josh Wolf, Heather McDonald, Carrot Top

Loni Love, Morgan Webb, Jo Koy

Brad Wollack, Perez Hilton, Chris Hardwick

Chris Franjola, Billy Gardell, Diablo Cody

Sarah Colonna, Michael Yo, Guy Branum

Arden Myrin, Ken Baker, Gary Valentine

Guy Branum, Natasha Leggero, Brad Wollack

Aries Spears, Josh Wolf, Whitney Cummings

Donnell Rawlings, John Caparulo, Jen Kirkman

Jennifer Irwin, Jo Koy, Loni Love

Heather McDonald, Jim Norton, Frank Nicotero

Jason Sklar, Randy Sklar, Michelle Biloon

Jeff Wild, Chris Franjola, Sarah Colonna

Guy Branum, Whitney Cummings, Brody Stevens

Natasha Leggero, Chris Hardwick, Rodney Perry

John Caparulo, Josh Wolf, Justin Guarini

Heather McDonald, Khloe Kardashian, Conor Knighton

Jo Koy, Jen Kirkman, Conor Knighton

George Wallace, Loni Love, Brad Wollack

Michael Yo, Heather McDonald, Ben Gleib

Sarah Colonna, Josh Wolf, T.J.

Guy Branum, Whitney Cummings, Kevin Hart

Chris Franjola, Candis Cayne, Ross Mathews

John Caparulo, Arden Myrin, Todd Glass

Jo Koy, Natasha Leggero, Joanna Coles

Jo Koy, Natasha Leggero, Joanna Coles

Jen Kirkman, Randy Sklar, Jason Sklar

John Caparulo, Loni Love, Ken Baker

Josh Wolf, Heather McDonald, Michael Yo

Brad Wollack, Janet Varney, Frank Nicotero

Chris Franjola, Whitney Cummings, Ben Gleib

Chris Hardwick, Hyla Matthews, Sarah Colonna

Jo Koy, Brad Wollack, Arden Myrin

Josh Wolf, Steve Marmalstein, Jen Kirkman

Greg Proops, Natasha Leggero, T.J. Miller

Heather McDonald, Chris Franjola, Jay Manuel

Jeff Wild, Guy Branum, Diablo Cody

Whitney Cummings, Randy Sklar, Jason Sklar

Jason Kennedy, Sarah Colonna, Josh Wolf

Chris Franjola, Bai Ling, Loni Love

Natasha Leggero, Jamie Kaler, Gary Valentine

John Caparulo, Jen Kirkman, Ross Mathews

Josh Wolf, George Wallace, Jen Kirkman

John Caparulo, Ross Mathews, Sarah Colonna

Loni Love, Brad Wollack, Heather McDonald

Bryan Callen, Chris Franjola, Ken Baker

Guy Branum, Arden Myrin, Chris Hardwick

Randy Sklar, Jason Sklar, Jeff Wild, Sarah Colonna

Jo Koy, Guy Branum, Christian Finnegan

Ben Gleib, Whitney Cummings, T.J. Miller

Singer and realitty TV star Brooke Hogan; Roundtable discussion with Michael Yo, Josh Wolf and Natasha Leggero

Actress and author Lauren Conrad on her new book "L.A Cabdy"; Roundtable discussion with Kevin Hart, Jo Koy and Jen Kirkman.

From "Weeds" actor Justin Kirk; comics Greg Proops, Sarah Colonna and Ross Mathews.

Award winning stage and screen actress Marissa Jaret Winokur; Roundtable discussion with comics Heather McDonald and John Caparulo

Model and actress Brooke Burke; Roundtable discussion with comics Chris Hardwick and Gary Valentine and actress Megyn Price.

Singer Michael Buble talks about his new live DVD, "Michael Buble Meets Madison Square Garden"; Roundtable Discussion with comics Josh Wolf, Brad Wollack and Whitney Cummings.

Award Winning actress and singer Florence Henderson; Roundtable discussion with comics Chris Franjola, Loni Love and Janet Varney.

From HawthoRNe actor Michael Vartan; roundtable disvussion with comics John Caparulo, Sarah Colonna and Ken Baker.

From "Drop Dead Diva" actress Margaret Cho; roundtable discussion with Jo Koy and the Sklar Brothers, Randy and Jason.

Award Winning singer Jewel Discuessed her new album, "Lullaby'; roundtable discussion with comics Heather McDonald, Chris Hardwick and T.J. Miller.

From "Van Wilder: Freshmen Year", Kristin Cavallari; roundtable discussion with comics Josh Wolf and Jen Kirkman and "The Insiders" Ross Mathews.

John Caparulo, Whitney Cummings, Billy Gardell

Actress and author Melissa Gilbert on her new autobiography, "Praire Tale: A Memoir"; comics Loni Love; comic Guy Branum; comic Brad Wollack.

Actor and comic Chris Kattan on his new mini series "Bollywood Hero"; comic Arden Myrin; comic Chris Franjola and Big Boy.

From "The Ugly Truth", actor Eric Winter; roundtable discussion with comics Eliot Chang, Gary Valentine and Greg Proops.

Actor and BBC tv personality, Graham Norton; roundtable discussion with comics Josh Wolf and the Sklar Brothers.

Actress Milla Jovovich on her new movie, "A Perfect Getaway"; roundtable discussion with comics Kevin Hart, John Caparula and Heather McDonald

Elisabeth Moss; Round table discussion with comics Chris Hardwick, Jo Koy, and Renee Gauthier.

Actress Jamie-Lynn Sigler on TV show "Entourage"; Round table discussion with comics Ben Gleib, Natasha Leggero, Michael Yo

Rapper Fabolous on his new album, "Loso's Way"; Round table discussion with comics Jo Koy, Jen Kirkman, and Billy Gardell.

Kourtney & Khloe Kardashian on their new show "Kourtney and Khloe Take Miami"; Round table disscussion with comics Brad Wollack, Sarah Colonna, and Tony Rock

TV host Jeff Lewis on new season of, "Flipping Out"; Round table discussion with comics Chris Franjola, Whitney Cummings, and Ross Mathews.

TV host Jonathan Ross discussing his show, "Friday Night with Jonathan Ross"; Round table discussion with comics Arden Myrin, Matt Braunger, and Guy Branum.

Musician Jason Aldean on his new CD, "Wide Open"; Round table discussion with comics John Caparulo, Loni Love, and Jamie Kaler.

Couple Giuliana and Bill Rancic discussing their new show, "Giuliana and Bill"; Round table discussion with comics Heather McDonald, Michael Kosta, and Josh Wolf.

Animal trainer Dave Salmoni on his new show, "Into the Pride"; Round table discussion with comics T.J. Miller, Natasha Leggero, and George Wallace.

Singer Reba McEntire on her new album, "Keep On Loving You"; Round table discussion with comics Sarah Colonna, Mo Mandel, and Guy Branum.

American boy band Backstreet Boys on their new album, "This Is Us"; Round table discussion with comics Chris Franjola, Dan Levy, and Ross Mathews.

Actor/Director Eli Roth on his new movie, "Inglourious Basterds"; Round table discussion with comics Gary Valentine, Jason Sklar, and Randy Sklar.

Actor/comic Kevin Nealon on his show, "Weeds"; Round table discussion with comics Brad Wollack, Jeff Wild, and Loni Love.

Actor Rex Lee on his show, "Entourage"; Round table discussion with comics Josh Wolf, Gina Yashere, and Chris Franjola.

Actress Rutina Wesley on her show, "True Blood"; Round table discussion with comics Jen Kirkman, Ben Gleib, and John Caparulo.

Actor/Model Antonio Sabato Jr. on his TV show, "My Antonio"; Round table discussion with comics Heather McDonald, Jason Kennedy, and Jo Koy.

Lead Singer/Songwriter/Guitarist Stephan Jenkins on his new album, "Ursa Major"; Round table discussion with comics Bryan Callen, Natasha Leggero, and Perez Hilton

Actor Jesse Metcalfe on his return to, "Desperate Housewives"; Round table discussion with comics Sarah Colonna, Michael Yo, and Guy Branum.

Actress Jane Lynch on her new show, "Glee"; Round table discussion with comics Josh Wolf, Renee Gauthier, Kevin Hart.

Singer Aaron Carter on joining, "Dancing With The Stars"; Round table discussion with comics John Caparulo, Donnell Rawlings, and Arden Myrin.

Actor Sam Trammell on his show, "True Blood"; Round table discussion with comics Brad Wollack, Loni Love, and Scott Henry.

Boxer Floyd Mayweather on his up coming fight; Round table discussion with comics Chris Hardwick, Greg Proops, and Natasha Leggero.

Actress Emily Procter on the new season of, "CSI:Miami"; Round table discussion with comics Randy Sklar, Jason Sklar, and Guy Branum.

Singer/Songwriter Nelly Furtado on her new album, "Mi Plan"; Round table discussion with comics Jeff Wild, Ross Mathews, and Whitney Cummings.

Actress Jennifer Aniston on her new movie, "Love Happens"; Round table discussion with comics Jen Kirkman, Josh Wolf, and Jo Koy.

Actor Rob Estes on his upcoming appearance in, "90210"; Round table discussion with comics Loni Love, Dr. Drew Pinsky, and Guy Branum.

Former Gov. Rod Blagojevich is promoting his memoir, "The Governor"; Round table discussion with comics Mark Curry, Brad Wollack, and Arden Myrin.

Actor Mekhi Phifer on his new role in the show, "Lie to me*"; Round table discussion with comics John Caparulo, Sarah Colonna, and Michael Kosta.

Model Caitlin Upton on her upcoming appearance in, "King of the Crown"; Round table discussion with comics Joe Matarese, Chris Franjola, and Natasha Leggero.

Comedian Lisa Lampanelli on her new memoir, "Chocolate, Please: My Adventures in Food, Fat, and Freaks"; Round table discussion with comics Jeffrey Ross, Ross Mathews, and Christian Finnegan.

Actor Alan Cumming on his one-man cabaret show, "Alan Cumming: I Bought a Blue Car Today"; Round table discussion with comics Matt Braunger, Whitney Cummings, and Jo Koy.

Actress Nia Long on her appearance in the documentry, "Good Hair"; Round table discussion with comics Michael Yo, Josh Wolf and Chris Hardwick.

Actress Sofia Vergara on her new show, "Modern Family"; Round table discussion with comics T.J. Miller, Jen Kirkman, and John Caparulo.

Singer/songwriter Joss Stone on her fourth studio album, "Colour Me Free"; Round table discussion with comics Heather McDonald, Johnny Sanchez, and Jason Sklar.

Karissa & Kristina Shannon, Crystal Harris on the new season of, "The Girls Next Door"; Round table discussion with comics Dan Levy, Chris Franjola, Loni Love.

Actor Abigail Breslin on her new movie, "Zombieland"; Round table discussion with comics Brad Wollack, Brody Stevens, and Guy Branum.

Actress Juliette Lewis on her new movie, "Whip It"; Round table discussion with comics Sarah Colonna, Bryan Callen, and Ben Gleib.

Father and daughter Lorenzo & Shayne Lamas on their new reality show, "Leave It to Lamas"; Round table discussion with comics Jo Koy, Jen Kirkman, and Lavell Crawford.

Actor Cory Monteith on his new show, "Glee"; Round table discussion with Ross Mathews, Josh Wolf, and Janet Varney.

Fashion designer Christian Siriano on his new book, "Fierce Style: How to Be Your Most Fabulous Self"; Round table discussion with comics John Caparulo, Gary Valentine, and Whitney Cummings.

Singer Kelly Osbourne and Louis Van Amstel talk about their appearance on, "Dancing With the Stars"; Round table discussion with comics Chris Hardwick, Hasan Minhaj, and Arden Myrin.

Author Carl Reiner on his new book, "Just Desserts"; Round table discussion with comics Heather McDonald, Randy Sklar, and Ross Mathews.

Comedian David Alan Grier on his new book, "Barack Like Me: The Chocolate-Covered Truth"; Round table discussion with comics Sarah Colonna, Chris Franjola, and Matt Braunger.

Comedian Mike Epps talks about hosting, "2009 BET Hip-Hop Awards"; Round table discussion with comics Brad Wollack, Natasha Leggero, and Ryan Stout.

Singer Brooke White on her up and coming tour with Michael Johns; Round table discussion with comics Guy Branum, Michelle Collins, and Bryan Callen.

Actor Katey Sagal on her show, "Sons of Anarchy"; Round table discussion with comics Loni Love, Josh Wolf, and Jo Koy.

Actress Jenny Mollen on her project, "Kidnapping Caitlynn"; Round table discussion with comics Jen Kirkman, Randy Sklar, and Jason Sklar.

Model Joanna Krupa;Round table discussion with comics Brad Wollack, Whitney Cummings, and Chris Hardwick.

Actress Susie Essman on her show, "Curb Your Enthusiasm"; Round table discussion with comics Heather McDonald, Kevin Hart, and Dan Levy.

Actress Gabrielle Union on her show, "FlashForward"; Round table discussion with comics John Caparulo, Jo Koy, and Arden Myrin.

Actress Valerie Bertinelli on her new book, "Finding It "; Round table discussion with comics Josh Wolf, Sarah Colonna, and Ross Mathews.

Newlyweds socialite Khloe Kardashian & NBA star Lamar Odom on their new marriage; Round table discussion with comics T.J. Miller, Chris Franjola, and Natasha Leggero.

Josh Wolf, Greg Proops, Jen Kirkman

Chris Hardwick, Maz Jobrani, Loni Love

Ross Mathews, Brad Wollack, Donnell Rawlings

Guy Branum, Bill Santiago, Whitney Cummings

Actress Julie Bowen talks about her show "Modern Family." Randy Sklar, Jason Sklar, Matt Braunger

Chelsea welcomes Justin Bieber. Ross Mathews, Jeff Wild, Sarah Colonna

50 Cent. Jo Koy, Chris Franjola, Heather McDonald

Jen Kirkman, Brad Wollack, Lawrence Leung

Guy Branum, Sarah Colonna, Wil Anderson

Heather McDonald, Chris Franjola, Josh Thomas

Brad Wollack, Guy Branum, Claire Hooper

Jo Koy, Jen Kirkman, Josh Wolf

Bill Gardell, Heather McDonald, Chris Hardwick

Ross Mathews, Chris Franjola, Christina Pazsitzky

Josh Wolf, Sarah Colonna, Bill Bellamy

Ryan Stout, Whitney Cummings, Jo Koy

Loni Love, Mo Mandel, Guy Branum

John Caparulo, Ross Mathews, Perez Hilton

Mom and daughter Kris and Kim Kardashian on their show, "Keeping up with the Kardashians." Brad Wollack, Steve Marmalstein, Arden Myrin

Natasha Leggero, Michael Yo, Jo Koy

Musician Adam Lambert discusses his album, "For Your Entertainment" :Round table discussion with comics Ross Mathews, Randy and Jason Sklar.

Josh Wolf, Matt Braunger, Jen Kirkman

Loni Love, Chris Franjola, Jeff Wild

Ross Mathews, Jo Koy, Sarah Colonna

Chris Hardwick, Ben Gleib, Heather McDonald

Brad Wollack, Jen Kirkman, Donnell Rawlings

John Caparulo, Greg Proops, Whitney Cummings

Snoop Dogg, Josh Wolf, Chris Franjola, Arden Myrin

We're starting off the new year with Robin Thicke and his Sex Therapy...like father like son. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Guy Branum are on the panel.

We're getting deep with Mary J. Blige and her new album, Stronger With Each Tear, word. Comedian Chris Hardwick, comedians Randy and Jason Sklar.

We're getting deep with Mary J. Blige and her new album, Stronger With Each Tear, word. Comedian Chris Hardwick, comedians Randy and Jason Sklar.

Holly Madison is dropping on by her old E! family today...we've missed her, too. Comedian Donnel Rawlings, comedian Heather McDonald and comedian Gary Valentine.

Word on the street is Giuliana and Bill Rancic are trying to have a baby. What're the odds that we'll get any sort of big announcement? Comedian Brad Wollack, comedian Natasha Leggero and comedian Matt Braunger.

We welcome back the very funny Aisha Tyler, from the new show Archer. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.

Amy Brenneman of Private Practice stops by, perhaps with some doctorly advice. Comedian John Caparulo, comedian Jen Kirkman and comedian Dan Levy.

Fist pumps all around for Jersey Shore's Snooki, Pauly D and The Situation. Comedian Chris Franjola, comedian Whitney Cummings and TV personality Ross Mathews.

David Arquette is back and telling us all about his new play The Female of the Species and the Golden Globes! Comedians Michelle Collins and Randy and Jason Sklar

Clear eyes, full hearts, can't lose with Legion's Adrianne Palicki (aka FNL's Tyra). Comedian Chris Hardwick, actress-comedian Arden Myrin and comedian Eric Price.

Who wouldn't be stoked that Kaley Cuoco from the megapopular Big Bang Theory is here? Comedian Heather McDonald, TV personality Ross Mathews and comedian Lavell Crawford.

James Van Der Beek is in the new movie Formosa Betrayed and popping up all over TV—even here! E!'s own Michael Yo, comedian Sarah Colonna and comedian Guy Branum.

We're beyond pleased to welcome back our animal guy Dave Salmoni and his new animal friends. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Mo Mandel.

We get down to business with The Office's Kate Flannery. Comedian Loni Love, comedian Dan Levy and comedian Whitney Cummings.

Things get really scandalous when author Jackie Collins stops by with her new book, Poor Little Bitch Girl. Comedian Chris Hardwick, comedian Jen Kirkman and comedian Jo Koy.

Lisa Edelstein from House is back again...Wait, so who's running Princeton Plainsboro? Comedian Josh Wolf, comedian Heather McDonald and comedian Ryan Stout.

House of Payne's Keshia Knight Pulliam is one hard working lady; Dr. Huxtable would be so proud. Comedian Loni Love, TV personality Rove McManus and comedian Michelle Collins

We're pretty thrilled that Danica Patrick makes a pit stop over at Chelsea Lately today. Comedian Josh Wolf, comedian Whitney Cummings and comedian Jo Koy.

Things might get wild with Radha Mitchell star of the new thrilling horror movie The Crazies. Comedian John Caparulo, comedian Bill Bellamy and actress-comedian Arden Myrin.

The Chelsea Lately cast do a Kardashian skit. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

From the new movie Cop Out we've got Seann William Scott in our custody today. Comedian Chris Hardwick and Comedians Randy and Jason Sklar.

Kendra and Hank Baskett are here to tell us all about the spellbinding new season of Kendra. E!'s own Michael Yo, comedian Sarah Colonna and comedian Jo Koy.

Please enjoy a very special Handler Edition of Single Staffers. Comedian Matt Bruanger, comedian Heather McDonald and comedian Moshe Kasher.

From Precious, the Academy Award-nominated Gabourey Sidibe is here. TV personality Ross Mathews, comedian Christina Pazsitzky and comedian Guy Branum.

Someone got some time away from the O.R., Grey's Anatomy's Kevin McKidd is here. Comedian John Caparulo, comedian Arden Myrin and comedian Chris Franjola.

Chelsea Chelsea Bang Bang is in stores now...You're welcome, everyone. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

Chelsea Chelsea Bang Bang is in stores now...You're welcome, everyone. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

Alexis Neiers, Gabrielle Neiers and Tess Taylor are here from their aptly titled new series on E! Pretty Wild. Comedian Brad Wollack, comedian Dan Levy and comedian Josh Wolf.

90210's Shenae Grimes is here to give us the deets on all things West Beverly. Comedian Bobby Lee, comedian T.J. Miller and comedian Whitney Cummings.

From the highly anticipated Diary of a Wimpy Kid, the purely entertaining Rachael Harris is here. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.

We catch up with Avril Lavigne, who sings "Alice," the title song from Tim Burton's Alice in Wonderland. Comedian Sarah Colonna, comedian/TV host Rove McManus and comedian Mo Mandel.

We're so thrilled to welcome the author of Where Mercy Is Shown, Mercy Is Given, Dog the Bounty Hunter. Comedian John Caparulo, comedian Heather McDonald and TV personality Ross Mathews.

Ludacris is back with his new album Battle of the Sexes and this time he's bringing drinks. Comedian Ben Gleib, comedian Natasha Leggero and comedian Guy Branum.

Johnny Weir is here, and unfortunately our show is not "on ice" this week. Comedian Jo Koy, comedian Lil JJ and comedian Sarah Colonna.

Chuy Bravo wrote a book, Little Nuggets of Wisdom, and he's here to share them. This, BTW, is all 100 percent for real, for real, girl. Comedian Heather McDonald, comedians Randy & Jason Sklar.

Author of The Day I Shot Cupid, Jennifer Love Hewitt is here. Comedian Brad Wollack, E!'s own Michael Yo and Comedian Mo Mandel,

Find out how spunky Chelsea can really be when TV Icon and star of Up Ed Asner stops by. Comedian Josh Wolf, comedian Loni Love and comedian Wil Anderson.

Things get real philanthropic up in here with Tom's Shoes founder Blake Mycoskie. Comedian Greg Behrendt, comedian Jen Kirkman and comedian Matt Braunger.

From the highly anticipated movie Date Night, the Academy Award-nominated Taraji P. Henson is here. Comedian Chris Franjola, comedian Chris Hardwick, TV personality Ross Mathews.

From BET's Tiny & Toya, BFFs Tiny & Toya are here. Comedian Whitney Cummings, actress Cloris Leachman and TV personality Ross Mathews.

Come celebrate a real milestone at Chelsea Lately—tonight's our 500th episode! Comedian Jo Koy, comedian Sarah Colonna and comedian Josh Wolf.

Resident animal expert Dave Salmoni is back with some hopefully furry friends. Comedian Dan Levy, comedian Arden Myrin and comedian Lavell Crawford.

Dancing With the Stars' hottest couple Erin Andrews and Maksim Chmerkovskiy. Comedian John Caparulo, comedian Heather McDonald and comedian Donnell Rawlings.

The man behind all things Shit My Dad Says, Justin Halpern is here. Comedian Bobby Lee, comedian Jen Kirkman and comedian Dov Davidoff.

Tonight we welcome Colin Hanks, one of The Good Guys from the new Fox drama. Comedian Heather McDonald, comedian Randy Sklar and musician Jeff Wild.

Clay Aiken is here, seriously, with his new CD Tried and True. Comedian Ben Gleib, comedian Loni Love and Comedian Gary Valentine.

Holly Madison is back with her new show Holly's World. Comedian Chris Hardwick, comedian Guy Branum and actress-comedian Arden Myrin.

True Blood is returning and Stephen Moyer is here, so get excited...or scared?! I'm not really sure. Comedian Jo Koy, comedian Eric Price and comedian Chris Franjola.

Star of all things Rescue Me the hilarious Denis Leary is here. Comedian Steve Marmalstein, comedian Natasha Leggero and TV personality Ross Mathews.

We're getting a little Lilith tonight when Sarah McLachlan stops by and talks her new album, Laws of Illusion. Comedian Jo Koy, E!'s own Michael Yo and comedian Sarah Colonna.

We're getting crunk with Lil Jon and his new album Crunk Rock…YEAAAAHHHH! Comedian John Caparulo, comedian Christina Pazsitzky and comedian Josh Wolf.

Learn how to make cupcakes with Roy and Charley tonight. Comedian Brad Wollack, comedian Dan Levy and comedian Bobby Lee.

Learn about the borderline amazing new As Seen on TV Products with A.J. Khubani. Comedian Chris Franjola, comedian Whitney Cummings and comedian Finesse Mitchell.

Star of In Plain Sight Mary McCormack graces us with her presence. Comedian Joe DeRosa, comedian Heather McDonald and comedian Josh Wolf.

Comedian Matt Braunger, comedian Moshe Kasher and comedian Guy Branum. Lakers champ Ron Artest tries to get into Chelsea's pants and chats about his NBA win. Plus, hear about his budding music career!

Actress Ashley Greene on her new movie, "The Twilight Saga: Eclipse"; Round table discussion with comics Mo Mandel, Arden Myrin, and Ross Mathews.

Rapper T.I. on his new album, "King Uncaged"; Round table discussion with comics Sarah Colonna, Jamie Kaler, and Josh Wolf.

From the most-anticipated movie in the country, Eclipse, Bryce Dallas Howard is here. Comedian Brad Wollack, comedian John Caparulo and comedian Christina Pazsitzky

Check out Chuy as the new spokesperson for Joe's Crab Shack...You're welcome crabs. Comedian Bobby Lee, comedian Jo Koy and comedian Ben Gleib

True Blood's favorite shapeshifter Sam Trammell is back. Comedian Bobby Lee, comedian Jo Koy and comedian Ben Gleib

Learn about the summer's best drinks with Belvedere's Claire Smith. Comedian Jason Sklar, comedian Natasha Leggero and comedian Gary Valentine

Pharrell does a lot, like producing the soundtrack and composing the score for Despicable Me. Comedian Jo Koy, comedian Whitney Cummings and TV personality Ross Mathews.

Kristin Cavallari is here and has all the info you're dying to know about the final season of The Hills. Comedian Chris Hardwick, comedian Heather McDonald and comedian Dov Davidoff

Canadian animal trainer Dave Salmoni on his new show, "Savaged with Dave Salmoni"; Round table discussion with comics Jason Sklar, Natasha Leggero, and Gary Valentine.

Actress Susan Sarandon on her upcoming reality ping-pong series; Round table discussion with comics Jo Koy, Ben Gleib, and Brad Wollack.

Sink your teeth into this: tonight we welcome Anna Paquin from HBO's True Blood. Rapper Lil John, rapper Big Boi and rapper Rick Ross.

Dust off your fists, girls, because Arsenio Hall is in the house. Comedian Chris Franjola, comedian Christina Pazsitzky and TV personality Ross Mathews

Actor Frank Grillo on his show, "The Gates"; Round table discussion with comics Loni Love, Josh Wolf, and Greg Proops.

Comedian Kathy Griffin on her show, "Kathy Griffin: My Life on the D-List"; Round table discussion with comics Jo Koy, Michael Yo, and Whitney Cummings.

Fry cook Chicken Charlie discusses frying food; Round table discussion with comics Chris Hardwick, Heather McDonald, and Rove McManus.

Actor Ron Livingston on his new film, "Dinner with Schmucks"; Round table discussion with comics Ross Mathews, Sarah Colonna, Guy Branum.

Tonight's guest is volleyball pro Gabby Reece. At the Round Table: John Caparulo, Christina Pazsitzky, Matt Braunger.

Tonight's guest is actress Lisa Lampanelli. At the Round Table: Brad Wollack, Jo Koy, James Van Praagh.

Fat Joe returns with his new album, The Darkside. Comedian Chris Franjola, actress-comedian Arden Myrin and TV personality Ross Mathews

From The Other Guys, Eva Mendes is here. Comedian Dan Levy, comedian Natasha Leggero and comedian Ben Gleib.

Star of Bravo's Bethenny Getting Married?, Bethenny Frankel is here. Comedian Josh Wolf, comedian Whitney Cummings and comedian Guy Branum

Margaret Cho tells us about her new comedy/music album Cho Dependent. Comedian Heather McDonald, comedian Hyla Mathews and TV personality Ross Mathews.

We're checking in with Alanis Morissette who's working her acting chops on the new season of Weeds. Comedian Bobby Lee, comedian Loni Love and comedian Dov Davidoff.

Extra Round Table. Comedian Jo Koy, comedian Sarah Colonna and comedian Jason Sklar

Grey's Anatomy star Kim Raver tells us about her foray into the Lifetime TV movie, Bond of Silence. Comedian Finesse Mitchell, actress-comedian Arden Myrin, and TV personality Ross Mathews

Kim and Kourtney Kardashian are here to make sure everyone is still Keeping Up With the Kardashians. Comedian Bill Bellamy, comedian Natasha Leggero and comedian Josh Wolf.

Jennifer Aniston is here telling us about her new film The Switch. Comedian John Caparulo, comedian Whitney Cummings and comedian Brad Wollack.

From the most frightening 3D movie of the summer, Piranha: 3D, Elisabeth Shue is here. Comedian Chris Franjola, comedian Owen Benjamin and comedian Jo Koy

Eli Roth tells us about his latest film The Last Exorcism. Comedian Chris Hardwick, comedian Sarah Colonna and comedian Gary Valentine.

Rufus Wainwright tells us about his tour and latest CD, All Days are Nights: Songs for Lulu. Comedian Josh Wolf, comedian Heather McDonald and musician Jeff Wild.

Jerry Springer tells us about his foray into game shows as host of GSN's Baggage. Comedian Randy Sklar, comedian Christina Pazsitzky and comedian Guy Branum.

Angie Harmon tells us about her hugely popular show Rizzoli & Isles. Comedian Ben Gleib, comedian Godfrey and comedian Jo Koy

Jewel returns and tells us about her new album, Sweet and Wild. Comedian Brad Wollack, comedian Natasha Leggero and comedian Steve Marmalstein.

Host of CW's Plain Jane Louise Roe is here to make over the staff of Chelsea Lately. Comedian Josh Wolf, comedian John Caparulo and musician Jo Koy.

You asked for more round table, tonight you're getting more round table. You're welcome, America. Comedian Chris Franjola, comedian Loni Love and comedian Joe DeRosa

Mel B. tells us about her new Style Network show Mel B: It's a Scary Life. Comedian Greg Proops, actress-comedian Arden Myrin and comedian-host Rove McManus.

R&B singer Ne-Yo on his new album, "Libra Scale "; Round table discussion with comics Michael Yo, Jen Kirkman, and Ross Mathews.

VMA performer and five-time nominee B.o.B is here with his No. 1 album B.o.B Presents: The Adventures of Bobby Ray. Comedian Matt Braunger, comedian Heather McDonald and comedian Josh Wolf.

An extra-long Round Table. You're welcome, America. Comedian T. J. Miller, comedian Sarah Colonna and comedian Dov Davidoff.

An extra-long Round Table. You're welcome, America. Comedian Ben Gleib, actress-comedian Whitney Cummings and comedian Jo Koy.

From Easy A, the can-do-no-wrong-in-my-book Emma Stone is here. Comedian Chris Hardwick, actress-comedian Arden Myrin and comedian Kevin Hart.

Get ready to GTL because Jersey Shore's Snooki and Pauly D are back. Comedian Donnell Rawlings, comedian Natasha Leggero and comedian Brad Wollack.

Usher has a new album, Versus, is on tour and is hanging out with us tonight, everyone rejoice. Comedian Loni Love, comedian Chris Franjola and musician Jeff Wild.

Jared Leto, lead singer of the band '30 Seconds to Mars.' Comedian John Caparulo, comedian Guy Branum and comedian Lavell Crawford

We welcome author of Dirty Sexy Politics, Meghan McCain. Comedian Josh Wolf, comedian Heather McDonald and comedian Gary Valentine.

Emily Rose from SyFy's Haven is here. Comedian Matt Braunger, comedian Sarah Colonna and comedian Mo Mandel.

We're pretty stoked that world-renowned surfer Laird Hamilton returns tonight. Comedian Jason Sklar, comedian Michelle Collins and comedian Jo Koy.

From the hilarious movie You Again, Jersey Shore's No. 1 fan Kristen Bell is here. Comedian Bobby Lee, comedian Whitney Cummings and TV personality Ross Mathews.

Adam Levine of Maroon 5 is here with their new album Hands All Over. Comedian Brad Wollack, comedian John Caparulo and writer Diablo Cody.

Star of Private Practice Taye Diggs is here…he may or may not be wearing a shirt. Comedian Jo Koy, comedian Dov Davidoff and comedian Natasha Leggero.

Parenthood's Dax Shepard is here to discuss many a things, one being his new film The Freebie. Comedian Chris Franjola, comedian Dan Levy and TV personality Ross Mathews.

AnnaLynne McCord is here to give us the 411 on all things 90210. Comedian Chris Hardwick, comedian Ben Gleib and actress-comedian Arden Myrin.

Dog the Bounty Hunter's Beth and Duane "Dog" Chapman grace our stage tonight. Comedian Moshe Kasher, comedian Heather McDonald and comedian Josh Wolf.

Tommy Lee is here with his latest Methods of Mayhem project A Public Disservice Announcement. TV personality Ross Mathews, comedian Whitney Cummings and comedian Guy Branum.

Cohost of E!'s Fashion Police, Kelly Osbourne, is here. Comedian Jo Koy, comedian Randy Sklar and comedian Loni Love.

The cowboy himself, Trace Adkins, is back with his new album Cowboy's Back in Town. Comedian Brad Wollack, comedian Chris Hardwick and comedian Natasha Leggero.

Cohost of the new CBS talk show The Talk, Leah Remini is here. Comedian Jo Koy, comedian Sarah Colonna and comedian Greg Proops.

Author of Sugar and Spice and Lauren Conrad Style the very busy Lauren Conrad is here. Comedian John Caparulo, comedian Josh Wolf and comedian Jim Breuer.

From Private Practice, the delightful Amy Brenneman returns to the show tonight. Comedian Chris Franjola, actress-comedian Arden Myrin and comedian Kevin Hart.

The biggest jackass of them all, Johnny Knoxville from Jackass 3D is here. Comedian Ben Gleib, comedian Loni Love and TV personality Ross Mathews.

The newest member of the Grand Ole Opry, Blake Shelton is here with his new album All About Tonight. Comedian Jo Koy, comedian Heather McDonald and E!'s own Michael Yo.

Rapper Lloyd Banks. Comedian John Caparulo, comedian Whitney Cummings and comedian Donnell Rawlings.

Jenny McCarthy is back with her latest book Love, Lust, and Faking It. Comedian Josh Wolf, musician Jeff Wild and comedian Guy Branum.

From the film Red Julian McMahon graces us with his presence tonight. Comedian Jo Koy, actress-comedian Arden Myrin, and TV personality Ross Mathews.

Milla Jovovich returns to tell us about her new film Stone. Comedian Josh Wolf, comedian Chris Franjola and comedian Gary Valentine.

Jennifer Nettles of Sugarland returns tonight with their new album The Incredible Machine. Comedian John Caparulo, comedian Sarah Colonna and comedian Chris Hardwick.

From Nick Swardson's Pretend Time comedian Nick Swardson is here. Comedian Brad Wollack, comedian Michelle Collins and comedian Bobby Lee.

Eddie Izzard from Showtime's United States of Tara is here. Comedian Jo Koy, comedian Natasha Leggero and comedian Ryan Stout.

Benji and Joel Madden are here to tell us all about Good Charlotte's new album Cardiology. Comedian Josh Wolf, comedian Heather McDonald and comedian Bill Bellamy.

Probably the most pregnant cast member of CSI: Miami, Emily Procter is here. Comedian Dan Levy, comedian Chris Franjola and comedian Sarah Colonna.

From dare I say the greatest television show of all time (Friday Night Lights), we welcome Tami Taylor herself, the Emmy-nominated Connie Britton. Writer Diablo Cody, comedian Guy Branum and TV personality Ross Mathews.

We've got YouTube sensation Keenan Cahill debuting his brand new video on the show tonight. Comedian Josh Wolf, comedian Chris Franjola and comedian Sarah Colonna

Kendra Wilkinson-Baskett is here to tell us all about the new season of her show Kendra. Comedian Jo Koy, comedian Matt Braunger and comedian Chris Hardwick

Find out how all of the stars align tonight with cosmic astrologists Starsky and Cox. Comedian Loni Love, comedian John Caparulo and TV personality Ross Mathews

Florence Welch, from one of this year's hottest acts, Florence + the Machine, is here. Comedian Jim Norton, comedian Brad Wollack and actress-comedian Arden Myrin

From one of the best shows on TV, Parenthood, Monica Potter is here. Comedian Josh Wolf, comedian Natasha Leggero and comedian Greg Proops

Trey Songz is bringing his Passion Pain and Pleasure (also the name of his new CD) to the show tonight, word. Comedian Jo Koy, comedian Heather McDonald and comedian T.J. Miller

Dancing With the Stars' extraordinary host and Deb's BFF (sorry, Gary) Tom Bergeron is here. Comedian Dan Levy, comedian Sarah Colonna and comedian Gary Valentine

Nelly is dropping by with his new album 5.0. This is for real, this is not just a dream...nailed it. Comedian Chris Franjola, E! News correspondent Michael Yo and TV personality Ross Mathews

It's the return of Single Staffers...just in time for the holiday season, you're welcome America! Comedian John Caparulo, actress-Comedian Arden Myrin and comedian Ryan Stout.

Dane Cook is here with his greatest hits album, I Did My Best. Comedian Jo Koy, comedian Kevin Hart and comedian Ben Gleib

Taylor Swift has a new album, called Speak Now, and she's here to tell us all about it. Topless comedian Brad Wollack, comedian Loni Love and comedian Gary Valentine

Animal expert Donald Schultz is here with an alligator, a prairie dog and a rattlesnake. Comedian Bobby Lee, comedian Whitney Cummings and TV personality Ross Mathews

One of the greatest gifts television has ever given us, John Stamos who's been guesting on Glee is here. Comedian Josh Wolf, comedian Heather McDonald and TV personality Ross Mathews

Flo Rida is here with his new album Only 1 Flo and hopefully some explanation for the state of Florida. Comedian Jo Koy, comedian Sarah Colonna and comedian Mo Mandel

Tonight we welcome The Lady Killer himself Cee-Lo Green. Topless Comedian Chris Hardwick, comedian Natasha Leggero and comedian Chris Franjola

From the new film The Warrior's Way Kate Bosworth is here. Comedian John Caparulo, comedian Matt Braunger and writer Diablo Cody

Comedian Josh Wolf, comedian Margaret Cho and TV personality Ross Mathews

Comedian Jo Koy, comedian Natasha Leggero and comedian John Caparulo

The incomparable Kevin Spacey is here to talk about his new film Casino Jack. Comedian Chris Franjola, comedian Whitney Cummings and E!'s own Michael Yo.

From One Tree Hill, Sophia Bush is here and were going to find out if she wants to be anything other than what she's been trying to be lately. Comedian Brad Wollack, actress-comedian Arden Myrin and comedian Dov Davidoff

One of our favorite people ever Zach Gilford is here to tell us about his new show Off the Map. Comedian Jo Koy, comedian Sarah Colonna and comedian Jason Sklar

The unmatched Roseanne Barr is here with her new book Roseannearchy. Comedian Josh Wolf, comedian Matt Braunger and TV personality Ross Mathews

Sara Bareilles and her chart topping album Kaleidoscope Heart are on the show tonight. Comedian Bobby Lee, comedian Loni Love and comedian T.J. Miller

Find out what Denis Leary has going on, hint: a new comedy special, a new book and the new Spider-Man movie. Comedian Josh Wolf, comedian Natasha Leggero and comedian Jason Sklar.

The newly engaged Ginnifer Goodwin from HBO's Big Love joins us tonight. Comedian Greg Proops, comedian Whitney Cummings, and TV personality Ross Mathews

Matt LeBlanc is here to tell us about the very funny new Showtime series he stars in, Episodes. Comedian Chris Franjola, writer Diablo Cody and comedian Dan Levy

TV host Piers Morgan on his new show, Piers Morgan Tonight; Round table discussion with comics Chris Hardwick, Rove McManus, and Jo Koy.

Actor Wilmer Valderrama on his new film, From Prada to Nada; Round table discussion with comics Gary Valentine, Ross Mathews, and Sarah Colonna.

Taraji P. Henson is back and has a lot going on including the new Lifetime movie Taken From Me: the Tiffany Rubin Story. Comedian Bobby Lee, actress-comedian Arden Myrin and comedian Ben Gleib

The headline-making director of the new film Red State, Kevin Smith is here. Comedian Brad Wollack, comedian Dov Davidoff and comedian Natasha Leggero.

Our good friend Kevin Nealon is here from the new movie Just Go With It. Comedian Joy Koy, E!'s own Michael Yo and comedian John Caparulo

Rachel Bilson is here from the new film Waiting for Forever. Comedian Bill Bellamy, comedian Whitney Cummings and comedian Chris Franjola

The staff plays in a men vs. women football challenge in honor of the upcoming Superbowl. Comedian Josh Wolf, comedian Heather McDonald and comedian Lavell Crawford.

Jennifer Aniston is back to tell us about her new movie Just Go With It. Comedian Chris Hardwick, comedian Sarah Colonna and comedian Ryan Stout

From the No. 1 movie in America The Roommate, Minka Kelly is here. Comedian Joy Koy, actress-comedian Arden Myrin and comedian Greg Proops.

James Blunt is here and he's got a new album called Some Kind of Trouble. Musician Jeff Wild, TV personality Ross Mathews and comedian Gary Valentine

From the new Fox drama The Chicago Code Jennifer Beals is here. Comedian Josh Wolf, comedian Loni Love and comedian Mo Mandel

Star of the film Justin Bieber: Never Say Never, Justin Bieber is here tonight. Comedian Jim Norton, comedian Heather McDonald and TV personality Ross Mathews

Fourteen-time Grammy Nominee Cyndi Lauper is here telling us about her new album, Memphis Blues. Comedian Joy Koy, comedian Fortune Feimster and comedian John Caparulo

Lo Bosworth, author of The Lo Down joins us tonight. Comedian Brad Wollack, comedian Natasha Leggero and comedian Wil Anderson

Donald Schultz is back with some new animal friends. Comedian Josh Wolf, comedian Jen Kirkman and comedian Joe Matarese

Emmy Rossum is here from the hit Showtime series Shameless. Happy Presidents Day, girl. Comedian Dan Levy, comedian Sarah Colonna and comedian Josh Wolf

Sports Illustrated swimsuit cover model Irina Shayk joins us tonight. Comedian Joy Koy, actress-comedian Arden Myrin and comedian Bobby Lee

Jason Biggs is here to tell us about his new show Mad Love. Comedian Joe DeVito, comedian Loni Love, and TV personality Ross Mathews

From the very funny new film Hall Pass Jason Sudeikis is here. Comedian Chris Franjola, writer Diablo Cody and comedian Ben Gleib

With her brilliant new album, 21, the fantastic Adele joins us tonight. Comedian Greg Fitzsimmons, comedian Heather McDonald and comedian Josh Wolf

Lil Jon, Shawty Putt and Chuy debut their new music video here tonight. Seriously. Comedian Chris Franjola, comedian Sarah Colonna and comedian Jo Koy

From the new movie Take Me Home Tonight, Anna Faris is here. Comedian Jeff Wild, comedian Natasha Leggero and TV personality Ross Mathews

Isla Fisher is here from the new film Rango. Comedian Brad Wollack, comedian Fortune Feimster and comedian Gary Valentine

We kick things off things in Australia with one of their faves, Sophie Monk. Comedian Chris Franjola, comedian Heather McDonald and comedian Celia Pacquola.

Musician Henry Rollins. Comedian Brad Wollack, comedian Heather McDonald and comedian Adam Richard

Zookeeper Nick De Vos is here tonight with some of his Australian animal friends. Comedian Jeff Wild, comedian Sarah Colonna and comedian Chris Franjola

Look who we ran into Down Under...Rihanna joins the show tonight. Comedian Josh Wolf, comedian Fortune Feimster and comedian Adam Hills

Singer Avril Lavigne on her new album, Goodbye Lullaby; Round table discussion with comics Brad Wollack, Natasha Leggero, and Matt Braunger.

Designer Vera Wang on her new fragrance, Preppy Princess; Round table discussion with comics Chris Hardwick, Jo Koy, and Sarah Colonna.

Actress Carla Gugino on her new film, Elektra Luxx; Round table discussion with comics Chris Franjola, Loni Love, and Greg Proops.

Brittany Snow from Harry's Law and the cover of Maxim joins us tonight. Comedian Jim Norton, comedian Jen Kirkman and TV personality Ross Mathews

Author of Pink Boots and a Machete, National Geographic's Mireya Mayor is here with some animal friends. Comedian Ben Gleib, comedian Fortune Feimster and comedian Josh Wolf.

Tonight we gladly welcome back country superstar Blake Shelton. E!'s own Michael Yo, comedian Heather McDonald and comedian Jo Koy

Legendary film producer and Jew Jerry Weintraub is here with his documentary, His Way. Comedian Joe Matarese, actress-comedian Arden Myrin and comedian John Caparulo

From Scream 4 Shenae Grimes is on the show tonight. Comedian Dov Davidoff, comedian Dan Levy and TV personality Ross Mathews

From the No. 1 film Hop, James Marsden joins us tonight. Comedian Brad Wollack, writer Diablo Cody and comedian Gary Valentine

Nutritionist and author or Body Confidence Mark Macdonald is here. Comedian Chris Hardwick, comedian Sarah Colonna and comedian Matt Braunger

Zooey Deschanel is here telling us about her new movie, Your Highness. Comedian Josh Wolf, comedian Erin Gibson and comedian Jo Koy

Actress Elizabeth Berkley is here with her new book Ask Elizabeth. Comedian Chris Franjola, comedian Jeff Wild and TV personality Ross Mathews

Anything can happen with Fringe's Joshua Jackson on the show tonight. Comedian Bobby Lee, comedian Heather McDonald and comedian Ryan Stout

Find out if Adam Brody lives of dies in Scream 4 tonight. Comedian Bill Bellamy, actress-comedian Arden Myrin and comedian Josh Wolf

JoAnna Garcia Swisher from Better With You joins us tonight. Comedian John Caparulo, comedian Jen Kirkman and comedian Greg Fitzsimmons

Want to go double or nothing (see Tuesday) on Hayden Panettiere living or dying in Scream 4? Comedian Fortune Feimster, comedian Natasha Leggero and comedian Sarah Colonna

From the new film The Conspirator Robin Wright is here. Comedian Josh Wolf, comedian Natasha Leggero and comedian Michael Yo

From Duran Duran Simon LeBon and Nick Rhodes are here to talk their latest CD All You Need Is Now. Comedian Ben Gleib, comedian Brad Wollack and comedian Jo Koy

Ziggy Marley tells us about his new comic book Marijuanaman tonight. Comedian Lavell Crawford, comedian Heather McDonald, and TV personality Ross Mathews

The very Swedish Malin Akerman is here tonight with her new movie The Bang Bang Club. Comedian Chris Franjola, comedian Loni Love and comedian Chris Hardwick

Gwyneth Paltrow is on the show tonight with her new book My Father's Daughter. Comedian Dan Levy, comedian-actress Arden Myrin and comedian Bobby Lee

The Pretty Reckless' Taylor Momsen talks Gossip Girl and her album Light Me Up. Comedian John Caparulo, comedian Sarah Colonna and comedian Jo Koy

Comedian Matt Braunger, comedian Jen Kirkman and comedian T.J. Miller

From In Plain Sight, our good friend Mary McCormack is here. Comedian Fortune Feimster, comedian Gary Valentine and TV personality Ross Mathews

Tyrese Gibson, from the No. 1 movie in America, Fast Five, is on the show tonight. Comedian Josh Wolf, comedian Heather McDonald and comedian Brad Wollack

From the new film Jumping the Broom the delightful Paula Patton is here. Comedian Chris Hardwick, comedian Loni Love and comedian Jo Koy

Melissa McCarthy is here from the very funny new movie Bridesmaids. Comedian Joe Matarese, comedian Chris Franjola and TV personality Ross Mathews

Dita Von Teese is here to fill us in on her latest endeavors including her MargaDita. Comedian Fortune Feimster, comedian John Caparulo and comedian Greg Fitzsimmons

From the new film Everything Must Go, Will Ferrell is here tonight. Comedian Jen Kirkman, comedian Whitney Cummings and comedian Jo Koy

Paul Bettany shows us he's an action star in his new film Priest tonight. Comedian Jeff Wild, comedian Sarah Colonna and comedian Chris Franjola

Judd Apatow is here to tell us about his new film Bridesmaids. Comedian Jim Norton, comedian Natasha Leggero and comedian Josh Wolf.

One of the hosts of E!'s Fashion Police Kelly Osbourne is on the show tonight. Comedian Fortune Feimster, comedian John Caparulo and comedian Loni Love

Kellan Lutz is here with his new film Love, Wedding, Marriage. Comedian Greg Proops, comedian Heather McDonald and comedian Jo Koy

From the very funny film Bridesmaids. Maya Rudolph is here. Comedian Josh Wolf, comedian Mo Mandel and TV personality Ross Mathews

We gladly welcome back Lucy Liu, star of Kung Fu Panda 2, to the show. Comedian Brad Wollack, actress-comedian Arden Myrin and E! News' Michael Yo

Our favorite dawg, American Idol's Randy Jackson is here and In It to Win It. Comedian Chris Hardwick, comedian Sarah Colonna and comedian Bobby Lee

From The Hangover Part II, Justin Bartha is on the show tonight. Comedian Ben Gleib, comedian Jo Koy and comedian Gary Valentine

Glee's Matthew Morrison is here and he has a new self-titled debut CD. Comedian Josh Wolf, comedian Dov Davidoff and Comedian Natasha Leggero.

Eva Mendes tells us about her latest film, Last Night, on the show tonight. Comedian Chris Franjola, comedian Jen Kirkman, and TV personality Ross Mathews.

Donald Schultz is back with some new animal friends. Comedian Whitney Cummings, comedian Chris Franjola and comedian Brad Wollack.

From the show Covert Affairs fellow New Jersian Piper Perabo is here. Comedian Matt Braunger, comedian Heather McDonald and comedian Josh Wolf.

Lucky magazine cover girl Lauren Conrad is here telling us all about her new clothing line. Comedian Chris Franjola, comedian Sarah Colonna and comedian Ben Gleib.

Author of Growing Up in Heaven, medium James Van Praagh is on the show tonight. Comedian Natasha Leggero, comedian Jo Koy and comedian Ryan Stout

Comedian-host Rove McManus, comedian Jen Kirkman and TV personality Ross Mathews

From Gene Simmons Family Jewels Gene Simmons rocks out with us tonight. Comedian Bobby Lee, actress-comedian Arden Myrin and comedian Josh Wolf

Star and executive producer of HawthoRNe Jada Pinkett Smith is here. Comedian Margaret Cho, comedian Fortune Feimster and TV personality Ross Mathews

Limp Bizkit has new album, Gold Cobra, and Fred Durst is here to tell us about it, and it's 2011. E! Correspondent Michael Yo, comedian Jo Koy and comedian Heather McDonald

If you're a big Padma Lakshmi fan—and who isn't—tune in tonight to learn all about Bravo's Padmathon. Comedian-host Chris Hardwick, comedian John Caparulo and comedian Josh Wolf

Connie Britton (Mrs. Coach!) from Friday Night Lights is here: Clear eyes, full hearts can't lose. Comedian Mo Mandel, comedian Loni Love and comedian Brad Wollack

Author of Found, Tatum O'Neal tells us all about her new show, Ryan & Tatum: The O'Neals. Comedian Greg Proops, comedian Natasha Leggero and comedian Chris Franjola.

Emily Mortimer from the highly anticipated Cars 2 is on the show tonight. Comedian Josh Wolf, comedian Jo Koy and comedian Sarah Colonna.

Ten-time world champion Pro Surfer Kelly Slater is here. Comedian Matt Braunger, actress-omedian Arden Myrin and TV personality Ross Mathews.

Gabourey Sidibe from The Big C makes her return to the show tonight. Comedian Greg Fitzsimmons, Comedian Jen Kirkman and comedian Whitney Cummings.

Tonight we welcome Liv Tyler from the movie The Ledge. Comedian Loni Love, comedian Jo Koy and comedian Gary Valentine

From Transformers: Dark of the Moon, Rosie Huntington-Whiteley is here. Comedian Fortune Feimster, comedian Josh Wolf and comedian Ben Gleib

Actress Jennifer Aniston on her new movie Horrible Bosses; Round table discussion with comics Jo Koy, Arden Myrin, and Chris Franjola

Actress Rosario Dawson on her new movie Fire with Fire; Round table discussion with comics Joe Matarese, Ross Mathews, and Sarah Colonna

From Horrible Bosses Jason Sudeikis is here. Comedian Jen Kirkman, comedian Josh Wolf and comedian Bobby Lee

Comedian John Caparulo, comedian Josh Wolf and comedian Loni Love

Round table comics include Michael Yo (@MichaelYo), Jen Kirkman (@JenKirkman) and Ross Mathews (@helloross). Tonight's guest is Joe Manganiello who plays the character Alcide on "True Blood".

Round table comics include Jeff Wild (@jiffywild), Natasha Leggero (@natashaleggero) and Jo Koy (@JoKoy).

Round table comics include Chris Franjola (@ChrisFranjola), Arden Myrin (@ArdinMyrin) and Bobby Lee (@bobbyleelive). Tonight's guest, Vanessa Carlton (@VanessaCarlton), just released her new CD "Rabbits OnThe Run".

Round table comics include Josh Wolf (@joshwolfcomedy), Gary Valentine (@Cmplmnt_Accptd) and Matt Braunger (@Braunger). Taryn Manning (@TarynManning) is on the show tonight to tell us about her latest film, "The Perfect Age of Rock 'n' Roll".

Round table comics include John Caparulo (@JohnCaparulo), Fortune Feimster (@fortunefunny) and Ben Gleib (@bengleib). We welcome back "America's Got Talent" judge Sharon Osbourne to the show tonight.

Martha Plimpton on her show Raising Hope; Round table discussion with comics Joe Matarese, Sarah Colonna, and Ross Mathews.

Actress Lisa Kudrow on her new show Web Therapy; Round table discussion with comics Jo Koy, Heather McDonald, and Brad Wollack.

Actress Mary McCormack on her show In Plain Sight; Round table discussion with comics Josh Wolf, Loni Love, and Ryan Stout.

Actor Michael Vartan from "Colombiana". Round table comics include Mo Mandel (@momandel), Arden Myrin (@ArdenMyrin) and Ross Mathews (@HelloRoss).

Actress Rose McGowan on her movie Conan The Barbarian 3D; Round table discussion with comics Jo Koy, Heather McDonald, and Bobby Lee.

Actress Bryce Dallas Howard on her movie The Help; Round table discussion with comics Chris Hardwick, Jen Kirkman, and Matt Braunger.

Country singer Trace Adkins on hosting American Country Awards; Round table discussion with comics Josh Wolf, Chris Franjola, and Fortune Feimster.

Actress Elizabeth Banks on her new movie The Hunger Games; Round table discussion with comics Josh Wolf, Sarah Colonna, and Greg Fitzsimmons.

Actor Denis Leary on the final season of Rescue Me; Round table discussion with comics Jo Koy, Loni Love, and Jeff Wild.

Actress Anne Hathaway on her movie The Dark Knight Rises; Round table discussion with comics Greg Proops, Heather McDonald, and Ross Mathews.

Actor Christopher Mintz-Plasse on his movie Fright Night 3D; Round table discussion with comics Brad Wollack, Fortune Feimster, and Dov Davidoff.

Round table guest host Ross Mathews with comics Chris Franjola (@ChrisFranjola), Arden Myrin (@ArdenMyrin) and Josh Wolf (@JoshWolfComedy). Tonight's guest is Joey Lawrence (@joeylawrence).

Round table comics include Ben Gleib (@BenGleib), Heather McDonald (@HeatherMcDonald) and Gary Valentine (@Gary_Valentine). Tonight's guest is Zoe Saldana (@zoesaldana).

Round table comics include Dov Davidoff (@Dovdavidoff), Sarah Colonna (@SarahColonna) and Matt Braunger (@Braunger). Tonight's guest, Rashida Jones, plays a big lesbian lawyer in "Our Idiot Brother".

Round table comics include Chris Hardwick (@nerdist),Jen Kirkman (@JenKirkman) and Ryan Stout (@StoutRyan). Jessica Chastain plays Celia Foote in "The Help".

Round table comics include Bill Bellamy (@BILLBELLAMY), Fortune Feimster (@fortunefunny) and Jo Koy (@Jokoy). "Jersey Shore's" Snooki is on the show tonight.

Round table comics include John Caparulo (@JohnCaparulo), Josh Wolf (@joshwolfcomedy) and Jeff Wild (@jiffywild). From MTV's "Awkward," Ashley Rickards (@AshRickards) is here.

Round table comics include Brad Wollack (@BradWollack), Heather McDonald (@HeatherMcDonald) and Greg Fitzsimmons (@GregFitzShow). Lake Bell from "A Good Old Fashion Orgy" is here.

Round table comics Jo Koy (@JoKoy), Arden Myrin (@ardenmyrin) and Gary Valentine (@Gary_Valentine). It's Labor Day America and we're celebrating with Usher and Belvedere tonight.

Round table comics include Chris Franjola (@ChrisFranjola), Iliza Shlesinger (@iliza) and Matt Braunger (@Braunger). Gloria Estefan (@GloriaEstefan) is here with the latest on her new album, "Miss Little Havana."

Dave Grohl is on the show tonight telling us all about the Foo Fighters album and tour. Comedian Bobby Lee, comedian Jen Kirkman and comedian Josh Wolf.

James Marsden from the movie Straw Dogs is on the show tonight. Comedian Chris Hardwick, comedian Sarah Colonna and comedian Ben Gleib.

Round table comics include Brad Wollack (@BradWollack), Loni Love (@LoniLove) and TJ Miller (@nottjmiller). Tonight's show...Chelsea's big headed brother, gay book agent & Chuy are cooking food for Rosh Hashanah.

Round table comics include Jo Koy (@JoKoy), Heather McDonald (@HeatherMcDonald) and Joe Matarese (@TheJoeMatarese). From the new movie "Bucky Larson: Born to Be a Star", Nick Swardson (@iAmNickSwardson) is here tonight.

Round table comics include Mo Mandel (@momandel), Natasha Leggero (@natashaleggero) and Gary Valentine (@Gary_Valentine). Kate Bosworth from the movie "Straw Dogs" is on the show tonight.

Round table comics include Greg Proops (@GregProops), Fortune Feimster (@fortunefunny) and Josh Wolf (@JoshWolfComedy). From the new show "Free Agents" Kathryn Hahn is here.

Round table comics include Michael Yo (@MichaelYo), Chris Franjola (@ChrisFranjola), Jo Koy (@Jokoy). From the new movie "50/50," Anna Kendrick (@AnnaKendrick47) is on the show tonight.

Round table comics include Moshe Kasher (@moshekasher), Sarah Colonna (@SarahColonna) and Ross Mathews(@HelloRoss). Anthony Mackie (@TheRealAmackie) is here telling us about his latest movie, "Real Steel."

Round table comics include Chris Hardwick (@nerdist), Jen Kirkman (@JenKirkman) and Lavell Crawford (@Lavellthacomic). Bush's Gavin Rossdale is on the show tonight with the latest on their new album, "Sea of Memories."

Round table comics include Bobby Lee (@bobbyleelive), Arden Myrin (@ardenmyrin) and Dov Davidoff (@dovdavidoff). Rachel Bilson is here telling us about her new show, "Hart of Dixie."

Round table comics include Jo Koy (@JoKoy), Whitney Cummings (@WhitneyCummings) and Ben Gleib (@BenGleib). From the new show "Ringer", tonight's guest is Sarah Michelle Gellar.

Round Table guests include John Caparulo, Tiffany Haddish, Josh Wolf and interview guest Kate Walsh.

Round Table guests include Fortune Feimster, Jim Breuer, Ross Mathews and interview guest Dylan McDermott.

Round Table guests include Brad Wollack, Heather McDonald, Ryan Stout and interview guest Cheryl Hines

Round table comics include Chris Franjola (@ChrisFranjola), Arden Myrin (@ArdenMyrin) and Gary Valentine (@Gary_Valentine).Tonight's guest is Emily VanCamp.

Round Table guests include Ross Mathews, Loni Love, Jeff Wild and interview guest Anna Faris.

Round Table guests include Jen Kirkman, Josh Wolf, Bill Bellamy and interview guest Jane Lynch.

Round table guest host Ross Mathews with comics Chris Franjola (@ChrisFranjola), Heather McDonald (@HeatherMcDonald), Michael Yo (@itsMichaelYo). Tonight Ross will interview Kendra Wilkinson-Baskett and Hank Baskett from "Kendra".

From the MTV series Good Vibes, Debi Mazar is here. Comedian Greg Fitzsimmons, comedian Sarah Colonna and comedian Bill Bellamy

From the movie The Ides of March Evan Rachel Wood is on the show tonight. Comedian Brad Wollack, comedian Jen Kirkman and comedian Matt Braunger.

Gloria Steinem is on the show telling us about her new film Gloria: In Her Own Words. Comedian Bobby Lee, comedian Fortune Feimster and comedian Chris Hardwick.

Actress and author of Devoted, Hilary Duff is here tonight. Comedian Gary Valentine, producer Dan Maurio and comedian Chris Franjola.

Orlando Bloom talks about his latest film The Three Musketeers on the show tonight. Comedian Josh Wolf, actress-comedian Arden Myrin and comedian Jo Koy.

Emilio Estevez is here telling us about his movie The Way. Comedian Ben Gleib, comedian Iliza Shlesinger and TV personality Ross Mathews.

Fashion icon Iman is on the show tonight. Comedian Mo Mandel, comedian Loni Love and comedian T.J. Miller.

Round table comics include John Caparulo (@JohnCaparulo), April Richardson (@Apey) and Ross Mathews (@HeeloRoss). Tonight's guest is Mike "The Situation" Sorrentino from MTV's "Jersey Shore".

Round table comics include Joe Matarese (@TheJoeMatarese), Natasha Leggero (@NatashaLeggero) and Josh Wolf (@JoshWolfComedy). Tonight's guest is T.I., a Grammy award winning rapper turned author whose debut novel titled, "Power and Beauty".

Round table comics include Jeff Wild (@jiffywild), Heather McDonald (@HeatherMcDonald) and Lavell Crawford (@Lavellthacomic). Tonight's guest is dancing his little tochus off on "Dancing With The Stars", David Arquette.

Round table comics include Brad Wollack (@BradWollack), Ali Wong (@aliwong3000) and Ryan Stout (@StoutRyan). Tonight's guest is a 4-time CMA female vocalist of the year and has just realeased her eleventh album titled, "Eleven", Martina McBride.

Round table comics include Dan Levy (@DanLevy), Arden Myrin (@ArdenMyrin) and Ross Mathews (@HelloRoss).

Round table comics include Bobby Lee (@BobbyLeeLive), Sarah Colonna (@SarahColonna) and Jo Koy (@JoKoy). Merry Christmas! Justin Bieber is here with his new album, "Under the Mistletoe".

From the new film Immortals, Stephen Dorff is here tonight. Comedian Moshe Kasher, comedian Fortune Feimster and comedian Josh Wolf

Star of iCarly Miranda Cosgrove is on the show tonight. Comedian Ben Gleib, comedian Loni Love and comedian Greg Fitzsimmons

Round table comics include Michael Yo (@MichaelYo), Jen Kirkman (@JenKirkman) and Gary Valentine (@Gary_Valentine). Tonight's guest is Dave Attell.

Round table comics include Chris Franjola (@ChrisFranjola), Tiffany Haddish (@TiffanyHaddish) and Josh Wolf (@JoshWolfComedy). Tonight's guest is animal naturalist David Mizejewski interviewed by guest host Ross Mathews.

Round table comics include Dan Maurio (@dmaurio), Hearther McDonald (@HeatherMcDonald) and Dov Davidoff (@DovDavidoff). Tonight's guest is Mindy Kaling from "The Office" and author of her new book "Is Everyone Hanging Out Without Me? (And Other Concerns)".

Round table comics include Brad Wollack (@BradWollack), Sarah Colonna (@SarahColonna) and T.J. Miller (@NotTJMiller). Tonights guest is Ellen Barkin from "Another Happy Day".

Tonight's guest, Kirsten Dunst, is the star of the film "Melancholia".

Round table comics include Sarah Colonna (@SarahColonna), Kerri Kenney-Silver (@kerrikenney) and Liz Carey (@thelizcarey). Tonight's guest is Denise Richards who stars in Spike's "Blue Mountain State".

Round table comics include Chris Hardwick (@nerdist), Fortune Feimster (@FortuneFunny) and Matt Braunger (@MattBraunger). Tonight's guest is Shailenne Woodley.

Round table comics include Jo Koy (@JoKoy), Loni Love (@LoniLove) and Josh Wolf (@JoshWolfComedy). Tonight's guest is Miranda Lambert.

Round table comics include Ben Gleib (@BenGleib), Heather McDoland (@HeatherMcDonald) and Bill Bellamy (@BILLBELLAMY). Tonight's guest is Miss Piggy.

Round table comics include John Caparulo (@JohnCaparulo), Jen Kirkman (@JenKirkman) and Ross Mathews (@HelloRoss). Tonight's guest is musical artist Drake.

Round table comics include Brad Wollack (@BradWollack), Natasha Leggero (@NatashaLeggero) and Josh Wolf (@JoshWolfComedy).

Round table comics include Bobby Lee (@Bobbyleelive), April Richardson (@Apey) and Chris Franjola (@ChrisFranjola). Tonight's guest is R&B Singer Ms. Mary J. Blige.

Round table comics include Greg Fitzsimmons (@GregFitzShow), Fortune Feimster (@FortuneFunny) and Josh Wolf (@JoshWolfComedy). Tonight's guest is Victoria Secret Angel Miranda Kerr.

Round table comics include Sarah Collona (@SarahColonna), Kerri Kenny-Silver (@KerryKenny) and Ross Mathews (@HelloRoss). Tonight's guests are the guys from "After Lately", Brad Wollack, Chris Franjola and Jiffy Wild.

Round table comics include Moshe Kasher (@moshekasher), Arden Myrin (@ArdenMyrin) and Gary Valentine (@Gary_Valentine). Tonight's guest is Whitney Cummings.

Round table comics include Jiffy Wild, Loni Love and Matt Braunger. Tonight's guest is actor Scott Porter.

Round table comics include Chris Franjola (@ChrisFranjola), Tiffany Haddish (@TiffanyHaddish) and Brad Wollack (@BradWollack). Tonight's guest is from "Happy Endings" on ABC, Casey Wilson.

Round table comics include John Caparulo (@JohnCaparulo), Heather McDonald (@HeatherMcDonald) and Ross Mathews (@HelloRoss). Tonight's guest is actor Gary Oldman.

Round table comics include Bobby Lee (@BobbyLeeLive), Jen Kirkman (@JenKirkman) and Dov Davidoff (@DovDavidoff). Tonight's guest stars in the new show "I Hate My Teenage Daughter", Jamie Pressly.

Round table comics include Josh Wolf (@Josh Wolf Comedy), Louis Virtel (@LouisVirtel) and Jo Koy (@JoKoy). Tonight's guest is Chloë Grace Moretz, staring in the movie "Hugo".

Round table comics include Margaret Cho (@MargaretCho), Fortune Feimster (@FortuneFunny) and Diablo Cody (@DiabloCody). Six-time Grammy Award winner Toni Braxton is on the show telling us about her show Braxton Family Values.

Round table comics include Dan Maurio (@dmaurio), Loni Love (@LoniLove) and Josh Wolf (@JoshWolfComedy). Hip Hop Artist and actor Common is here to tell us about his new album, The Dreamer, The Believer, and his show, Hell on Wheels.

Ben Gleib, Natasha Leggero, Ross Mathews

Round table comics include John Caparulo, Sarah Colonna and Bill Bellamy. Tonight's guest is Kenneth Branagh.

Round table comics include Mo Mandel, Heather McDonald and Greg Fitzsimmons. Tonight's guest is Robin Thicke.

Round table comics include Josh Wolf, Jen Kirkman and Joe Matarese. Tonight's guest is Patton Oswalt.

Round table comics include Michael Yo, Fortune Feimster & Ross Mathews. A New Year's Cooking Segment with Chef Roy Handler.

Round table comics include Michael Yo (@MichaelYo), Jen Kirkman (@JenKirkman) and Josh Wolf (@joshwolfcomedy). Emmy Rossum is here telling us all about season two of ”Shameless”.

Round table comics include Jo Koy (@JoKoy), Loni Love (@LoniLove) and Ross Mathews (@HelloRoss). Robin Wright is on the show telling us about her latest movie ”The Girl with the Dragon Tattoo”.

Round table comics include Chris Franjola, Whitney Cummings and Gary Valentine. Wu-Tang's RZA is here telling us about his new role on Showtime's ”Californication”.

Round table comics include Brad Wollack, Arden Myrin and Dov Davidoff. From the new NBC sitcom ”Are You There Chelsea?”, Laura Prepon is on the show tonight.

Host of the People�s Choice Awards Kaley Cuoco tells us about her new Lifetime movie Drew Peterson: Untouchable. Comedian John Caparulo, Comedian Natasha Leggero, and Comedian Ryan Stout.

From the new ABC show GCB Kristin Chenoweth is on the show. Comedian Jeff Wild, Comedian Heather McDonald, and Comedian Josh Wolf.

Pauly D is back on the show tonight to tell us all about the new season of Jersey Shore. Comedian Mo Mandel, Comedian Fortune Feimster, and Comedian Lavell Crawford.

Host of Real Time with Bill Maher and author of The New New Rules, Bill Maher is here. Comedian Bobby Lee, Comedian Sarah Colonna, and Comedian Matt Braunger.

Giovanni Ribisi. Round table comics include Ali Wong, Chris Franjola and Kerri Kenney-Silver.

Kim Wayans. Round table comics include Josh Wolf, Natasha Leggero and Greg Fitzsimmons.

Round table comics include Moshe Kasher, Heather McDonald and Ben Gleib. Tonight's guest is Amy Brenneman,

Kate Beckinsale. Round table comics include Louis Virtel, Arden Myrin and Loni Love.

Alexa Chung, Round table comics include April Richardson, John Caparulo and T.J. Miller, guest host Ross Mathews.

Round table comics include Joe Matarese, Fortune Feimster and Matt Braunger. Tonight's guest is Glee star Dot-Marie Jones with guest host Ross Mathews

Round table comics include Bill Bellamy, Sarah Colonna and Chris Franjola. Tonight's guest is Real Housewives of Beverly Hills star Lisa VanderPump with guest host Ross Mathews.

Round table comics include Bobby Lee, Liz Carey and Josh Wolf. Tonights guest is The Meatball Shop Guys with guest host Ross Mathews.

Round table comics include Brad Wollack, Jen Kirkman and Dov Davidoff. Tonight's guest is Wanda Sykes.

Round table comics include Chris Franjola, Heather McDonald and Gary Valentine. Tonight's guests are Jenny McCarthy & Sabra Ricci.

Round table comics include Michael Yo, Natasha Leggero and Josh Wolf. Tonight's guest is Don Cheadle.

Round table comics include Dan Maurio, Ross Mathews, Heather McDonald. Tonight's guest is Kristen Bell.

Round table comics include Josh Wolf, Ben Gleib, Sarah Colonna. Tonight's guest is Piers Morgan.

Round table comics include Matt Braunger, Jeff Wild and Ross Mathews. Tonight's guest is Kelly Rowland.

Round table comics include John Caparulo, Mo Mandel and Arden Myrin. Tonight's guests are The Wanted.

Round table comics include Bobby Lee, Fortune Feimster and Ryan Stout. Tonight's guest is LeeAnn Rimes.

Round table comics include Brad Wollack, Ali Wong and Greg Fitzsimmons. Tonight's guest is Christa Miller.

Round table comics include Chris Franjola, Loni Love and T.J. Miller. Tonight's guests are Stella Starsky & Quinn Cox.

Round table comics include Josh Wolf, Kerri Kenney-Silver and Lavell Crawford. Tonight's guest is Reese Witherspoon.

Round table comics include Natasha Leggero, Heather McDonald and Jo Koy. Tonight's guest is Lenny Kravitz.

Round table comics include John Caparulo, Jen Kirkman and Whitney Cummings. Tonight's guest is Amanda Seyfried.

Round table comics include Ross Mathews, Arden Myrin and Josh Wolf. Tonight's guest is Jennifer Aniston.

Round table comics include Lavell Crawford, Tiffany Haddish and Loni Love. Tonight's guest is Gabourey Sidibe.

Round table comics include Bobby Lee, Sarah Colonna and Gary Valentine. Tonight's guest is Tyler Perry.

Round table comics include Brad Wollack, Heather McDonald and Kerri Kenney-Silver. Tonight's guest is Maria Sharapova.

Round table comics include Dan Maurio, Natasha Leggero and Matt Braunger. Tonight's guest is Ellen Pompeo.

Round table comics include Ben Gleib, Michael Yo and Ross Mathews. Tonight's guest is Dr. Mehmet Oz.

Round table comics include Joe Matarese, Fortune Feimster and Chris Franjola. Tonight's guest is Jake Owen.

Round table comics include Dan Levy, Sarah Colonna and Jo Koy. Tonight's guest is Idina Menzel.

Round table comics include John Caparulo, Jen Kirkman and Ross Mathews. Tonight's guest is Geoff Stults.

Round table comics include Josh Wolf, Arden Myrin and Dov Davidoff. Tonight's guest is Julianne Moore.

Round table comics include Jeff Wild, Natasha Leggero and Bobby Lee. Tonight's guest is Jennifer Westfeldt.

Round table comics include Ali Wong, Fortune Feimster and Heather McDonald. Tonight's guest is Stanley Tucci.

Round table comics include Mo Mandel, Loni Love and Gary Valentine. Tonight's guest is Josh Gad.

Round table comics include Brad Wollack, Kerri Kenney-Silver and Josh Wolf. Tonight's guest is Leslie Bibb.

Round table comics include Chris Franjola, Natasha Leggero and Ross Mathews. Tonight's guest is Shirley Manson.

Josh Wolf, Jen Kirkman, T.J. Miller.

Ross Mathews, April Richardson, Lavell Crawford.

Dan Levy, Arden Myrin, Bill Bellamy.

Moshe Kasher, Heather McDonald, Bobby Lee.

Ross Mathews, Fortune Feimster, Jo Koy.

Ben Gleib, Sarah Colonna, Greg Fitzsimmons.

John Caparulo, Liz Carey, Josh Wolf

John Caparulo, Heather McDonald, Ryan Stout.

Michael Yo, Loni Love, Chris Franjola.

Josh Wolf, Jen Kirkman, Dov Davidoff.

Jeff Wild, Arden Myrin, Brad Wollack.

Ali Wong, Sarah Colonna, Ross Mathews.

Mo Mandel, Liz Carey, Jo Koy.

Ben Gleib, April Richardson, Josh Wolf.

Greg Fitzsimmons, Fortune Feimster, Gary Valentine.

John Caparulo, Arden Myrin, T.J. Miller.

Dan Levy, Heather McDonald, Lavell Crawford.

Brad Wollack, Loni Love, Josh Wolf.

Chris Franjola, Jen Kirkman, Matt Braunger.

Sarah Colonna, Dan Maurio, Ryan Stout.

Michael Yo, Natasha Leggero, Gary Valentine.

Ben Gleib, Fortune Feimster, Dov Davidoff.

Jeff Wild, Kerri Kenney-Silver, Ross Mathews.

Jen Kirkman, Mo Mandel, Brad Wollack.

Ross Mathews, Heather McDonald, Jo Koy.

John Caparulo, Rachel Feinstein, Josh Wolf.

Chris Franjola, Loni Love, Greg Fitzsimmons.

Brody Stevens, Sarah Colonna, Josh Wolf.

Moshe Kasher, Arden Myrin, Brad Wollack.

Dan Levy, Fortune Feimster, T.J. Miller.

Natasha Leggero, April Richardson, Ross Mathews.

John Caparulo, Ali Wong, Chris Franjola.

Gary Valentine, Heather McDonald, Matt Braunger.

Ben Gleib, Jen Kirkman, Ross Mathews.

Dan Maurio, Loni Love, Mo Mandel.

Michael Yo, Sarah Colonna, Josh Wolf.

Jen Kirkman, Morgan Murphy, Brad Wollack.

Jeff Wild, Natasha Leggero, Kerri Kenney-Silver.

With guest host Fortune Feimster

Ben Gleib, Margaret Cho, Ross Mathews.

James Davis, Heather McDonald, Mo Mandel.

Greg Fitzsimmons, Loni Love, Matt Braunger.

Chris Franjola, Jen Kirkman, Dov Davidoff.

Joe Matarese, Sarah Colonna, Brad Wollack.

John Caparulo, Jen Kirkman, T.J. Miller.

Bobby Lee, Heather McDonald, Keith Robinson.

Michael Yo, Fortune Feimster, Ross Mathews.

Jeff Wild, Brad Wollack, Josh Wolf.

Brody Stevens, Natasha Leggero, Ross Mathews.

Chris Franjola, Lauren Lapkus, T.J. Miller.

April Richardson, Heather McDonald, Loni Love.

In her opening monologue, host Chelsea Handler celebrates an early Canada Day (July 1). Chelsea and her round table panelists Mo Mandel, Arden Myrin and Ross Mathews discuss E.L. James and her agent coming out with a product line around her book "Fifty Shades of Grey", the US government revoking their $20 million of funding to develop a Pakistani version of Sesame Street due to alleged corruption in the puppet theater world, a University of Kansas study in which basic personality traits of people could be determined through the type of shoes they wore, and a boot camp for kids who watch too much Internet porn. Chelsea shows an employee review done for Heather and Xiao. And Chelsea chats with guest Erin Wasson about her new movie Abraham Lincoln: Vampire Hunter and the screenings she attended for the US military in the Persian Gulf and northeast Africa, her gift to Chelsea of a head massager, being from Dallas, and a half donkey/half zebra called a zonkey. Written by Huggo

Round table guests include Ben Gleib, Jen Kirkman, Josh Wolf and interview guest Oliver Stone.

Liz Carey, Sarah Colonna, Fortune Feimster.

John Caparulo, Natasha Leggero, Josh Wolf.

Round table guests include Ben Gleib, Rachel Feinstein, Ross Matthews and interview guest Meghan McCain.

James Davis, Sarah Colonna, Gary Valentine.

Jeff Wild, Heather McDonald, Ryan Stout.

Chris Franjola, Lisa Kyong Thrash, Brad Wollack.

Ali Wong, Fortune Feimster, Ross Mathews.

Michael Yo, Arden Myrin, Matt Braunger.

Bobby Lee, Jen Kirkman, Marc Maron.

John Caparulo, Natasha Leggero, Greg Fitzsimmons.

Trevor Noah, Sarah Colonna, Ross Mathews.

Dan Maurio, Loni Love, Josh Wolf.

Kerri Kenney-Silver, Heather McDonald, Dov Davidoff.

With guest host Wanda Sykes.

With guest host Kevin Hart.

With guest host Kevin Hart.

With guest host Dax Shepard.

Jeff Wild, Loni Love, Matt Braunger.

John Caparulo, Lauren Lapkus, Mo Mandel.

Heather McDonald, Gary Valentine, Lil Rel Howery.

Michael Yo, Sarah Colonna, Ryan Stout.

Josh Wolf; April Richardson; Marc Maron.

James Davis; Fortune Feimester; Brad Wollack.

Chris Franjola; Arden Myrin; Ross Mathews.

Ben Gleib; Jen Kirkman; Greg Fitzsimmons.

Dan Maurio, Kerri Kenney-Silver, Matt Braunger.

Sarah Colonna, Loni Love, Ryan Stout.

John Caparulo, Ali Wong, Ross Mathews.

Michael Yo, Heather McDonald, T.J. Miller.

Ben Gleib, Mary Lynn Rajskub, Josh Wolf.

Chris Franjola, Fortune Feimster, Kurt Braunohler.

Brad Wollack, April Richardson, Gary Valentine.

Jen Kirkman, Morgan Murphy, Dov Davidoff.

With guest host Rebel Wilson.

Guest host Loni Love

Guest host Fortune Feimster

Guest host Whitney Cummings

Guest host Josh Wolf

Snooki and JWoww chat up Season 3 of their reality series on MTV.

Interviewee: Julian Lennon Panelists: Ian Karmel, Claire Titelman, Thomas Dale

Interviewee: Casey Wilson Panelists: Chris Franjola, Annie Lederman, Ross Mathews

Interviewee: Kate Bosworth Panelists: Michael Polish, John Caparulo, Jen Kirkman, Greg Proops

Interviewee: Kat Dennings Panelists: Dan Levy, Fortune Feimster, Loni Love

Interviewee: Tom Hiddleston Panelists: Brad Wollack, Arden Myrin, Ryan Stout

Interviewee: Stephen Amell Panelists: Dov Davidoff, Jessimae Peluso, Ross Mathews

Interviewee: Kelly Osbourne Panelists: Kerry Kenney-Silver, Jamie Lee, Jo Koy

Interviewee: TBA Panelists: Jeff Wild, Sarah Colonna, Gary Valentine

Chelsea Handler talks about the things she has in common with Miley Cyrus. Chelsea and her round table panelists John Caparulo, Sarah Tiana and Ross Mathews discuss Cyrus smoking a joint on stage at the MTV EMA's, Tom Cruise's deposition that his job is as grueling as fighting the war in Afghanistan, and California legislators discussing a law that would require porn actors to wear goggles to protect their eyes from exposure to bodily fluids. And Chelsea's guest, former White House chef Sam Morgante, prepares some of the Commander in Chiefs' favorite dishes.

Chelsea Handler talks about her thoughts on the recent Miss Universe Pageant. Chelsea and her round table panelists April Richardson, Josh Wolf and Loni Love discuss Chelsea being in trouble with the Catholic League for a joke she made about having an abortion, Sarah Palin's latest book about what she perceives to be the war on Christmas, the upcoming Single's Day in China, a cat caught smuggling marijuana into a prison in Moldova, and why Chelsea's dog is currently wearing a collar. And Chelsea chats with guest Avril Lavigne.

Chelsea Handler talks about the similarities between herself and female apes. Chelsea and her round table panelists James Davis, Heather McDonald and Matt Braunger discuss Chelsea's love of animal porn, Mike Tyson's autobiography in which confesses he used cocaine while he was boxing and used a fake penis filled with urine to pass drug tests, New Jersey Governor Chris Christie's cover story in Time magazine, and Bruce Jenner now sporting a ponytail. Chelsea shows her post interview debrief with Nicole 'Snooki' Polizzi and 'Jenni 'Jwoww' Farley' . And Chelsea chats with guest Tim Allen.

From Scandal, Kerry Washington is here. Roundtable guests include Ben Gleib Cameron Esposito and Julian McCullough.

Chelsea Handler talks about why now is only the second time in her life that she is excited about Canada. Chelsea and her round table panelists Michael Yo, Jen Kirkman and Ross Mathews discuss the latest goings-on in the life of crack smoking Toronto mayor Rob Ford, the Indonesian boy who started smoking at age two now giving it up at age five replacing that addiction with junk food, Chris Brown being released from anger management rehab early so that he can start his community service.

Chelsea Handler talks about why she loves country music. Chelsea and her round table panelists Greg Fitzsimmons, Annie Lederman and Ian Karmel discuss crack-smoking Toronto mayor Rob Ford and his brother councilor Doug Ford's new talk show being canceled after one episode, the Cheney daughters' public feud about homosexuality, Kanye West's latest music video featuring him having sex with wife Kim Kardashian, West's feud with President Barack Obama, and new home STD tests. And Chelsea chats with guest Josh Gad about his latest movie Frozen (2013)

Chelsea Handler talks about the difficulties and consequences of having a female roommate. Chelsea and her round table panelists Kerri Kenney-Silver, Whitney Cummings and Jo Koy discuss Adam Levine being named People magazine's latest sexiest man alive, Whitney's latest boyfriend, a video montage compiled by CNN of Toronto mayor Rob Ford as a human wrecking ball, and an Elle magazine article about women leaving straight relationships later in life to enter into a homosexual relationship. And Chelsea chats with guest Sam Claflin about his latest movie The Hunger Games: Catching Fire.

Chelsea Handler talks about animal porn. Chelsea and her round table panelists Moshe Kasher, Alice Wetterlund and Kurt Braunohler discuss the concept of MTV's new documentary program called Generation Cryo (2013), TMZ reporting that the real reason Chris Brown left rehab early was that he was asked to by the facility for his behavior, Britney Spears' new song called "Perfume", a Brazilian woman attempting for the second time to sell her virginity online for $1.5 million, and a London company that delivers beer to office workplaces on Fridays.

In her opening monologue, host Chelsea Handler talks about the consequences of the reconstruction of the driveway at her house. Chelsea and her round table panelists Liz Carey, Loni Love and Gary Valentine discuss highlights from this past weekend's American Music Awards 2013 (2013), Daniel Day-Lewis' son Gabriel-Kane Day-Lewis performing rap, and a fried chicken scented candle. Chuy's knowledge of Thanksgiving is tested. And Chelsea chats with guests Florida Georgia Line about their latest CD "Here's to the Good Times: This Is How We Roll".

Chelsea Handler talks about Chuy's advice to her about health care. Chelsea and her round table panelists Jeff Wild, Sarah Colonna and Chris Franjola discuss Fortune's latest adventure in Las Vegas, Alec Baldwin's talk show being canceled because he used homosexual slurs in public, the trip to Tokyo that many of Chelsea's staff took last week, Josh Brolin checking himself into rehab, and a lesbian waitress stating that a couple didn't give her a tip since they didn't agree with her lifestyle. And Chelsea chats with guest Mary J. Blige.

Chelsea Handler talks about the symbiosis between Thanksgiving and Hanukkah. Chelsea and her round table panelists John Caparulo, Arden Myrin and Ryan Stout discuss Dr. Conrad Murray stating that he held Michael Jackson's penis every night and that the two used to make fun of Jackson's ex-wife Debbie Rowe, Kanye West mounting a boycott Louis Vuitton campaign because company representatives would not meet with him, the James Franco/Seth Rogen spoof of the Kanye West/Kim Kardashian music video, pubic hair coming back in style based on sheer laziness.

Chelsea Handler talks about how being at the stage of life she's at affected her Thanksgiving. Chelsea and her round table panelists Heather McDonald, Fortune Feimster and Thomas Dale discuss the fights that broke out on Black Friday shopping trips, the Kardashians' artistic Christmas card, Joe Jonas talking about when he smoked pot for the first time and when he lost his virginity, and Amazon experimenting with a new delivery system using unmanned drones. And Chelsea chats with guest Mike Tyson about his new book "Undisputed Truth".

Chelsea Handler talks about what booze will do to some people's eating habits, especially one specific person on her staff. Chelsea and her round table panelists Dan Levy, April Richardson and Josh Wolf discuss Pope Benedict XVI announcing that he used to be a bouncer, Elton John's shows in Russia possibly being canceled because of Russia's anti-gay laws, Google no longer auto-correcting certain words, Kanye West commissioning Andy Warhol's cousin to paint a portrait of Kim Kardashian.

Chelsea Handler talks about what is more important in the news than the Obamacare website now working. Chelsea and her round table panelists Ben Gleib, Sarah Tiana and Matt Braunger discuss Katy Perry and John Mayer's Vanity Fair portraits, British diver Tom Daley announcing that he's dating a man while still remaining straight, a University of Buffalo study that found that couples who drink together but that don't over-imbibe have a lower divorce rate, and a whiskey filled Advent calendar. And Chelsea chats with guest Orlando Bloom about his latest movie.

Chelsea Handler talks about taking every opportunity to liven up an event, but one event for which she has not been able to do that. Chelsea and her round table panelists Ian Karmel, Jamie Lee and Dov Davidoff discuss Lady Gaga's record sales declining, a movie theater in Florida accidentally showing the adult Nymphomaniac (2013) when it was supposed to show the family-friendly Frozen (2013), the increase in the prescription of Adderall for a variety of issues, and a Kenyan man sentenced to ten years in prison for raping a goat.

Australian author Bradley Trevor Greive is on the guest list.

Adam Scott is interviewed.

Kristen Bell talks up Season 3 of "House of Lies."

Idris Elba is on the guest list, along with panelists Nick Swardson, Sarah Colonna and Michael Rosenbaum.

Amy Adams is interviewed. On the panel: Moshe Kasher; Fortune Feimster; Dov Davidoff.

An interview with Zosia Mamet. Also: Heather McDonald, Julian McCullough and Gary Valentine are on the panel.

Taylor Schilling is interviewed. On the panel: Giulia Rozzi; Josh Wolf; Loni Love.

John Leguizamo promotes his movie "Ride Along." On the panel: Leah Remini; Mary McCormack; Whitney Cummings.

Kendall and Kylie Jenner promote the Season 9 premiere of "Keeping Up With the Kardashians."

Heather Graham is interviewed. On the panel: John Caparulo, Claire Titelman and Ross Mathews.

Emmy Rossum talks about Season 3 of "Shameless." Ben Gleib is on the panel, along with April Richardson and Ryan Stout.

David Spade ("The Spoils of Babylon") is on the guest list.

Gabourey Sidibe talks about her role on "American Horror Story: Coven." On the panel: Kerri Kenney-Silver; Natasha Leggero; Bobby Lee.

Timothy Olyphant chats about Season 5 of "Justified." On the panel: Michael Yo; Jamie Lee; Ross Mathews.

Andy Samberg is interviewed. On the panel: Moshe Kasher; Loni Love; and Gary Valentine.

Gabrielle Union is interviewed. On the panel: Ron G; Heather McDonald; Ian Karmel.

Emma Roberts is interviewed. On the panel: Chris Franjola; Sarah Colonna; Dustin Ybarra.

Vanessa Hudgens is interviewed. On the panel: John Caparulo; Fortune Feimster; Julian McCullough.

Michelle Monaghan ("True Detective") is on the guest list. Panelists: Natasha Leggero; Sarah Tiana; Whitney Cummings.

Mariska Hargitay is interviewed. On the panel: Jo Koy; Janine Brito; Ross Mathews.

Emma Kenney ("Shameless") is on the guest list. Panelists: Brody Stevens; Jen Kirkman; Kurt Braunohler.

Director McG ("3 Days to Kill"). Also: Jeff Wild, Cameron Esposito and Matt Braunger are on the panel.

Sharon Osbourne.

Chelsea celebrates Fashion Week. On the panel: Eliza Skinner; Lovi Love; Ryan Stout.

Alison Brie is interviewed. On the panel: Kerri Kenney-Silver; Liza Treyger; Josh Wolf.

Demi Lovato is interviewed.

Guest host Ross Mathews

Alex Pettyfer is on the guest list.

Scott Speedman talks about his role in the comedy "Barefoot."

Kurt Russell chats about starring in "The Art of the Steal." On the panel: Sarah Colonna, Moshe Kasher and Fortune Feimster.

Julianne Moore appears in support of her film "Non-Stop." On the panel: Jen Kirkman, Beth Stelling and Jo Koy.

Sarah Paulson is interviewed. On the panel: John Caparulo, Morgan Murphy and April Richardson.

Figure skaters Tara Lipinski and Johnny Weir are interviewed. Also: Dov Davidoff, Whitney Cummings and Tone Bell are on the panel.

Michelle Dockery of "Downton Abbey" is interviewed. On the panel: Kurt Braunohler, Fortune Feimster and Dustin Ybarra.

Cameron Diaz chats about writing "The Body Book."

Guest host Gabourey Sidibe

Guest host Khloe Kardashian

Guest host Mary McCormack

Minnie Driver is interviewed.

Chelsea chats with Emily Mortimer about the HBO comedy series "Doll & Em."

Adam Levine is interviewed.

A pastor thinks the movie "Frozen" has a gay agenda, Steven Tyler is allegedly dating his younger assistant, passengers on a Carnival Cruise want lifetime retribution, and from "Tyler Perry's Single Moms Club" Tyler Perry is here.

L.A had an earth quake this morning, the Malaysian airplane is still missing, Guinness beer pulls out of Saint Patrick's Day Parade, and from "Catch a Contractor" Adam Carolla is here.

The Pope refused to meet with Russell Crowe, Billy D Williams performed on "Dancing With The Stars", the couple from "Little Couple, Big World" are separating and from "Divergent" Theo James is here.

George Clooney has a new girlfriend, John Mayor is sueing Charlie Sheen's friend, The Duke porn star is getting rich, and from "Enlisted" Geoff Stults is here.

Johnny Weir and his husband split up, Selfies are causing a rise in plastic surgery, Is Malaysian Flight 370 somewhere off the coast of Australia, and snowboard champion Shaun White is here.

Drew Brees is interviewed.

Jayma Mays is interviewed.

Rapper Rick Ross is interviewed.

Bradley Trevor Greive stops by with cute baby animals.

Demián Bichir.

Mark Cuban is interviewed.

Don Cheadle is interviewed.

Mindy Kaling is interviewed.

Jamie Foxx is interviewed. Also: John Caparulo, Beth Stelling and Brad Wollack appear on the panel.

Sebastian Stan chats about his role in "Captain America: The Winter Soldier." On the panel: Kerri Kenney-Silver; Dustin Ybarra; and Heather McDonald.

Nikolaj Coster-Waldau is interviewed.

Comedian Amy Schumer is interviewed. On the panel: April Richardson; Sarah Colonna; and Ross Mathews.

Marlon Wayans is interviewed.

Singer-songwriter Ellie Goulding is interviewed. On the panel: Bobby Lee; Whitney Cummings; and Julian McCullough.

Brooklyn Decker is interviewed. On the panel: Michael Yo; Loni Love; and Matt Braunger.

Guest host Khloe Kardashian

Guest host T.J. Miller

Guest hosts Loni Love

Guest host Mary McCormack

Giuliana and Bill Rancic are interviewed.

Hugh Dancy ("Hannibal") is on the guest list.

Helen Hunt discusses her role in the film "Decoding Annie Parker."

Neon Trees' frontman Tyler Glenn is interviewed.

Rapper 2 Chainz is interviewed. On the panel: Julian McCullough; Brad Wollack; and Liz Carey.

Jane Lynch is interviewed. On the panel: Chris Franjola; April Richardson; Gary Valentine.

Arianna Huffington is interviewed. On the panel: Jen Kirkman; Kevin Christy; and Josh Wolf.

Dave Franco is interviewed. On the panel: Nick Thune; Ian Karmel; Heather McDonald.

Connie Britton is interviewed.

Sandra Oh is interviewed.

Jason Priestley chats about his memoir.

"Nurse Jackie" star Edie Falco is on the guest list.

Evan Peters is on the guest list. On the panel: Ron Funches, Sarah Tiana and Brad Wollack.

Australian rapper Iggy Azalea is interviewed. On the panel: Michael Yo; Bobby Lee; and Jo Koy.

Charlize Theron is interviewed.

Drew Barrymore and Adam Sandler are interviewed.

Joel McHale is interviewed.

Terry Crews is interviewed.

Sarah Silverman.

Lea Michele is interviewed.

Kelly Osbourne is on the guest list.

Giovanni Ribisi is interviewed. On the panel: Jeff Wild, Natasha Leggero and Josh Wolf.

Singer Austin Mahone is interviewed.

Colin Hanks is interviewed.

Lena Headey is interviewed.

Chelsea chats with Channing Tatum.

Jenny Slate chats about her movie "Obvious Child." On the panel: Liza Treyger; Jen Kirkman; Julian McCullough.

Rob Riggle is interviewed. On the panel: Moshe Kasher; Fortune Feimster; and Bobby Lee.

Jason Biggs ("Orange Is the New Black") is interviewed.

The cast of the Lifetime reality series "Little Women: LA" are on the guest list. Panelists include Greg Fitzsimmons, Sarah Tiana and Julian McCullough.

Laverne Cox ("Orange Is the New Black"). On the panel: Chris Franjola; Michael Yo; Josh Wolf.

Meagan Good appears in support of her movie "Think Like a Man Too." Also: Ben Gleib, Fortune Feimster and Ryan Stout are on the panel.

Kevin Hart is interviewed.

Jenna Dewan-Tatum chats about Season 2 of her Lifetime drama "Witches of East End."

Comedian Gabriel Iglesias is on the guest list.

Chris Rock is interviewed. On the panel: Brody Stevens; April Richardson; and Jo Koy.

Eric Bana is interviewed about his starring role in the thriller "Deliver Us From Evil."

Melissa McCarthy is interviewed. On the panel: Jeff Wild; Loni Love; Brad Wollack.

Susan Sarandon is interviewed. On the panel: Chris Franjola; Arden Myrin; Kurt Braunohler.

Bel Falcone is interviewed.

Model Chrissy Teigen is interviewed. On the panel: Josh Wolf; Loni Love; Gary Valentine.

Dane Cook is on the guest list. On the panel: Ben Gleib; Bobby Lee; Ross Mathews.

Cameron Diaz is interviewed. On the panel: Mary McCormack; Whitney Cummings; Julian McCullough.

Dean Norris ("Under the Dome") is interviewed.

Lela Loren is interviewed.

Frank Grillo, star of "The Purge: Anarchy," is interviewed.

Natasha Lyonne and Uzo Aduba, stars of "Orange Is the New Black," are interviewed.

John C. Reilly is interviewed.

Kelsey Grammer is interviewed.

Chris Pratt is interviewed.

Country music artist Jake Owen is on the guest list.

Ethan Hawke is interviewed.

NBA player Chandler Parsons.

Megan Fox is interviewed.

Liv Tyler ("The Leftovers") is interviewed.

In her opening monologue, host Chelsea Handler talks about what she did today at the studio on this the last day of the show, including the last communal shower she had in the Chelsea Lately shower facility. Chelsea and Chuy bring on her current stable of round table regulars. What Chelsea believes is going to be three of her closest celebrity friends, Mary McCormack - her best friend - Jennifer Aniston, and Sandra Bullock, providing a gracious send-off ends up being what they hope will be more useful for Chelsea's life. Chelsea's ex-lover 50 Cent and G-Unit perform their new single, "Watch Me". Chuy, via a prepared video, talks about what this show and Chelsea have meant to him. Miley Cyrus, in tribute to it being the last show, performs the pop classic, "It's Over". And many of Chelsea's musical friends, and some non-musical friends, help her serenade E!, to who she is grateful for the past seven years.